Solid Tumors and Metastasis

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Hematopoietic Stem Cells and Leukemia

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IFNalpha activates dormant haematopoietic stem cells in vivo (Nature, 2009)

Model showing the activating effects of short-term (acute) IFNa stimulation on dormant/quiescent HSCs, and the inhibitory effects of chronic IFNa treatment on HSC self-renewal

Essers, M.A., Offner, S., Blanco-Bose, W.E., Waibler, Z., Kalinke, U., Duchosal, M.A., & Trumpp, A. (2009). IFNalpha activates dormant haematopoietic stem cells in vivo. Nature, 458(7240), 904-908. doi: 10.1038/nature07815

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