Solid Tumors, Metastasis & Therapy Resistance

Hematopoietic Stem Cells and Leukemia

Stem Cells and Tumor Microenvironment

HI-STEM Group Leaders

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Model showing the activating effects of short-term (acute) IFNa stimulation on dormant/quiescent HSCs, and the inhibitory effects of chronic IFNa treatment on HSC self-renewal
Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A (2009). "IFNalpha activates dormant haematopoietic stem cells in vivo." Nature 458.7240: 904908. https://doi.org/10.1038/nature07815

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