Solid Tumors, Metastasis & Therapy Resistance

Hematopoietic Stem Cells and Leukemia

Stem Cells and Tumor Microenvironment

HI-STEM Group Leaders

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After waking up the hematopoietic stem cells, bone marrow of normal mice (left) is packed with blood cells whereas the bone marrow of Fanconi mice is severely depleted, the blood cells have been replaced by fat cells. © Michael Milsom, DKFZ

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F.B., Huntscha, S., Sobotta, M.C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., Muedder, K., Klein, C., Jauch, A., Schroeder, T., Geiger, H., Dick, T.P., Holland-Letz, T., Schmezer, P., Lane, S.W., Rieger, M.A., Essers, M.A., Williams, D.A., Trumpp, A., & Milsom, M.D. (2015). Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature, 520(7548), 549-552. doi: 10.1038/nature14131

Links and further information

Pubmed | Read at Publisher
DKFZ Press Release (englisch)
DKFZ Pressemitteilung (German)