September 04, 2019
We are Hiring!

We are looking for Junior Research Group Leader to set up an independent group within HI-STEM

HI-STEM is currently looking for a Junior Group Leader to set up a new independent group within HI-STEM and the DKFZ. If you are interested to join our team, please find more information in this job advertisement. It is also availabe online at Nature Jobs.…
July 18, 2019
NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Making cancer stem cells visible to the immune system - New results may enable innovative treatment concept against leukemia (New publication in Nature)

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for natural killer (NK) cells. This protective mechanism can be tricked with drugs. The exciting finding has been made by colleagues of the Trumpp team from…
July 11, 2019

A new tool to study hematopoiesis in detail: Optimized multicolor immunofluorescence panel differentiating major steps of blood development published in Cytometry (OMIP‐059)

The mammalian blood system is one of the best-researched hierarchical stem cell systems. It is also a main focus of the research in HI-STEM as it is a key for the understanding of the development of hematopoietic stem cells (HSCs) and the catastrophic…
June 05, 2019

Her Honour Lieutenant Governor of Ontario Elizabeth Dowdeswell visits HI-STEM

On June 4th, as part of her visit of the DKFZ, her Honour Lieutenant Governor of Ontario Elizabeth Dowdeswel (@LGLizDowdeswell) visited the HI-STEM Lab. As part of her tour she showed great interest in our research on the role of stem cells in cancer.…
April 11, 2019

International Symposium FOR 2033: The Hematopoietic Niches; Munich, May 10th-11th, 2019

Marieke Essers is co-organizing the International Symposium "The Hematopoietic Niches" together with her colleagues from the DFG-funded NicHem Research Group. For further details and the full program please see the conference website.
April 02, 2019
The HI-STEM Founding Team celebrates ten years of successful cooperation: Friedrich von Bohlen, Managing Director dievini Hopp BioTech Holding, Josef Puchta, Administrative Director DKFZ, Heike Bauer, Head Dietmar Hopp Stiftung, Dietmar Hopp Founder and Managing Director Dietmar Hopp Foundation, Andreas Trumpp, HI-STEM Managing Director, Michael Baumann, DKFZ Managing Director, Christof Hettich, Co-Managing Director dievini Hopp BioTech Holding (from left to right) | © Stefan Hebling

Ten Years of HI-STEM – Founding Team Celebrates Successful Partnership on Cancer Stem Cell Research

Ten years ago, HI-STEM, the Heidelberg Institute for Stem Cell Technology and Experimental Medicine, started its work within the newly renovated labs of the German Cancer Research Center (DKFZ). On the occasion of this anniversary, the founders have drawn a…
February 14, 2019

The long non-coding RNA Meg3 is highly and specifically expressed in HSCs, but surprisingly is not required for hematopoiesis – New Publication in Scientific Reports

In this study, we have addressed the role of the imprinted long non-coding RNA (lncRNA) Meg3 and its associated miRNA cluster for adult hematopoietic stem cell (HSC) function. Meg3 is highly and specifically expressed in adult HSCs, but not in progenitor or…
February 10, 2019

Cell-culture Medium for pancreatic cancer cells co-developed by Miltenyi Biotec and HI-STEM now on sale

Based on an ongoing collaboration between HI-STEM and the German Biotech Company Miltenyi Biotec GmbH, our cell-culture medium for tumor cells from the pancreas is now available for sale at Miltenyi. The medium is an improved version of the one described in…
February 07, 2019

Congratutions to Dr. Mattia Falcone for sucessfullly defending his PhD Thesis on BCAT1 in Leukemia!

Congratulazioni Mattia! Want to read more on his work? Here is the main paper of his thesis:
February 04, 2019

HI-STEM lab visited by Tino Sorge, Member of the German Bundestag

Today, Tino Sorge has visited the HI-STEM lab as part of the 1st German Cancer Research Congress (GCRC). Andreas Trumpp took the opportunity to explain how modern cancer research at the HI-STEM lab and the DKFZis pivotal for the development of innovative and…
December 20, 2018

Human blood cells can be directly reprogrammed into neural stem cells - New Publication in Cell Stem Cell

In the study, which was led by HI-STEM postdoc Marc Thier, we have succeeded for the first time to directly reprogram human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the…
December 09, 2018
Andreas Trumpp together with Minister of Science and Education Theresia Bauer

Prestigious award for Andreas Trumpp

The State Research Prize for Applied Research (Landesforschungspreis) of Baden-Württemberg 2018 is awarded to Andreas Trumpp. The Minister for Science, Research and Art Theresia Bauer presented the award, which includes a prize money of 100.000 Euro, during a…
November 30, 2018

Marieke Essers receives the Prize of the Berlin-Brandenburg Academy of Sciences and Humanities

The Berlin-Brandenburg Acadamy of Sciences and Humanities (BBAW) is honoring Marieke Essers pioneering research work on hematopoietic stem cells and their activation during stress conditions such as inflammation. The award is donated by the Monika Kutzner…
September 19, 2018
Participants of the 2018 F. C. Behr-Symposium

International Behr-Symposium on Stem Cells and Cancer

From September 16-19, 2018, HI-STEM, together with the DKFZ and the Heidelberg University Hospital, was hosting the 10th International Heinrich F.C. Behr-Symposium on Stem Cells and Cancer. The conference featured talks by over 25 invited international…
September 19, 2018

HI STEM researchers show link between stress signaling and chemotherapy resistant metastasis in breast cancer

In collaboration with physicians in Heidelberg and Mannheim, the group of Thordur Oskarsson at HI-STEM and DKFZ published a research paper in EMBO Molecular Medicine on September 6, 2018, ahead of print. The first author Jacob Insua-Rodríguez, a member of the…
July 30, 2018
Andreas Trumpp

Andreas Trumpp elected as Board Member of the European Association for Cancer Research (EACR)

The European Association for Cancer Research (EACR) is Europe’s professional membership association for those working and studying in cancer research, with more than 10,000 members worldwide. Its mission is “The advancement of cancer research for the public…
July 20, 2018

HI-STEM Teams Win Gold and Silver at the DKFZ’s Sommerfest Cup!

HI-STEM Researchers do not only know how to deal with stem cells but also how to score as was shown during the 2018 DKFZ Summer Party. Two mixed teams started both defeating all other teams leading to a double victory for out two teams!
May 07, 2018

New Review in Cell Stem Cell: Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

Classically, stem and progenitor populations have been considered discrete homogeneous populations. However, recent technological advances have revealed significant hematopoietic stem cell (HSC) heterogeneity, with evidence for early HSC lineage segregation…
April 04, 2018

Double sucess for HI-STEM researchers Simon Haas and Simon Raffel

Two awards at once, both carrying high monetary prizes, go to two HI-STEM members: Simon Raffel will receive the 2017 Walter Schulz Prize for his discovery how misregulated breakdown of amino acids in leukemia stem cells promotes blood cancer. To find out…
March 21, 2018

Ten years of successful research on cancer stem cells at HI-STEM – Third funding period announced!

Since its installation in 2008, HI-STEM can look back at ten years of successful research. On March 28, 2018, the Dietmar-Hopp Foundation and the DKFZ have announced that the funding for HI-STEM will be prolonged until 20203. Additionally two new projects on…
March 16, 2018

HI-STEM participates in UniStem Day 2018

Today, over 200 high-school students have visited the DKFZ to learn more about stem cells and their potential for applications in medicine. The UniStem Day is an international endeaveour to educate young people. In Germany it is organized in parallel at…
February 09, 2018

Marieke Essers receives the Chica and Heinz Schaller Research Award

On February 5, 2018, the Chica and Heinz Schaller Research Award were presented to HI-STEM Group Leader Marieke Essers during the official award ceremony at Heidelberg University. She received the award for her pioneering work on hematopoietic stem cells and…
January 23, 2018

Regulating Stem Cell Function from Long Distances: HI-STEM Team and Colleagues Describe New Layers of Myc Regulation in Nature

In the publication, which appeared online at Nature.comon January 17, 2018, the regulation of Myc by a modular gene enhancer in the normal hematopoietic system and in leukemia is described. The study, which was driven forward by Carsten Bahr, PhD Student at…
November 23, 2017

Nature Paper on BCAT1 overexpression in leukemia featured in Cancer Discovery

Our recent Nature paper on BCAT1 overexpression in leukemia has been featured in the Research Watch section of Cancer Discovery: High BCAT1 Expression Mimics IDH Mutations in Acute Myeloid Leukemia | Cancer Discovery

Misregulated protein breakdown promotes leukemias and brain cancer – new HI-STEM Publication online in Nature

Nov 10, 2017 2326
In the new paper published online at on November 8, we describe how high…

HI-STEM Mini-Symposium

Aug 17, 2017 1482
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HI-STEM Mini-Symposium on Normal and Malignant Hematopoietic Stem Cells on August 28 The…

Major honor: Prince William and Duchess Catherine have visited the DKFZ and HI-STEM labs

Jul 25, 2017 1537
Prince William and his wife, Duchess Catherine, visited the HI-STEM laboratory on July 20, 2017
As part of their official visit to Germany, Prince William and his wife, Duchess…

HI-STEM group leader receives David B. Frohnmayer Award.

Jan 27, 2017 2309
Dr. Michael Milsom was recently awarded the 2016 Fanconi Anemia Research Fund’s David B.…

Mechanism of therapy resistance in pancreatic cancer uncovered

Feb 25, 2016 812
Scientists at HI-STEM have uncovered a yet unknown mechanism for therapy resistance in…

Oncogene controls stem cells during pregnancy – HI-STEM Paper featured as cover story in Cell

Feb 15, 2016 532
February 15, 2016 In a process called diapause, many animal species delay the development…

HI-STEM scientist’s work recognized with DKFZ award

Jan 27, 2016 3207
Dr. Dagmar Walter and Dr. Amelie Lier were awarded the 2015 Waltraud Lewenz prize for…

Andreas Trumpp featured in GSCN Video Clip on Stem Cell Research

Nov 06, 2014 482
The German Stem Cell Network (GSCN) has produced a video with Andreas Trumpp on Stem Cell…

Federal Chancellor Angela Merkel visits the German Cancer Research Center

Apr 23, 2014 390
On the occasion of the 50th birthday of the DKFZ, the German Chancellor Angela Merkel…