March 31, 2020

Hidden messages in mRNA transcripts: Alternative polyadenylation (APA) is a novel control mechanism enabling hematopoietic stem cells (HSC) to adapt their activity to emergency situations– new publication in Cell Stem Cell

A team of researchers around Pia Sommerkamp, who carried out her PhD thesis in the HI-STEM lab and now continues as a Postdoc, now reports alternative polyadenylation (APA) as a new layer of gene regulation. In their study, the team, which involved colleagues…
March 24, 2020
Lung metastasis in a breast cancer patient: the arrows indicate fibroblasts (brown) that communicate with metastatic cancer cells. Cell nuclei are stained blue. © Oskarsson, DKFZ/HI-STEM

How tumor cells create a metastatic niche – new work from the Oskarsson lab published in Nature Communications

In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'. Maren Pein and colleagues from the Oskarsson lab within HI-STEM and DKFZ…
March 13, 2020

LeukoSystem: New BMBF-funded eMed Junior Consortium to investigate leukaemia causes and therapies

The LeukoSyStem consortium, which is coordinated by HI-STEM group leader Simon Haas, investigates leukaemia stem cells in acute myeloid leukaemia (AML). The German Federal Ministry of Education and Research (BMBF) financially supports this collaboration with…
February 19, 2020
Andreas Trumpp © Jutta Jung/DKFZ

German Cancer Prize Awarded to Andreas Trumpp

On February 19, 2020, Andreas Trumpp, Managing Director of HI-STEM and Division Head at the German Cancer Research Center (DKFZ), will receive the German Cancer Prize in the 'Experimental Research' category for his trailblazing work on identifying cancer stem…
January 07, 2020
Three dimensional segmentation of a bone marrow region. Different niche cells (green and red dots) and blood vessels (grey) are highlighted. | © DKFZ, EMBL and University Hospital Zurich

New paper out on Nature Cell Biology: 3D atlas of the bone marrow - in single cell resolution

The lastest paper from the group of Simon Haas was published by Nature Cell Biology shortly before Christmas last year. This is the result of a great team effort together with colleagues at the DKFZ and HI-STEM. The published methods are able to reveal the…
December 10, 2019
Highly Cited 2019

Andreas Trumpp recognized as Highly Cited Researcher 2019

Andreas Trumpp has been recognized as a "Highly Cited Researcher" by the recently announced Web of Science list for 2019. The list recognizes "the world's most influential researchers of the past decade, demonstrated by the production of multiple highly-cited…
November 12, 2019
Plakt ÜBERLEBENSSTRATEGIEN

ÜBERLEBENSSTRATEGIEN: Science Communication Event with colleagues from the Stem Cell SFB (CRC873)

On November 21, Andreas Trumpp will give a public presentation on "Stem Cells and Cancer" as part of the event series Überlebensstrategien / Survival Strategies. The presentations will be in German. Survival Strategies is a joint project of the Life Science…
October 11, 2019

Mick elected into representative roles within both EHA and ASH.

Mick Milsom has recently been elected as a chair of the Molecular Hematopiesis Workshop of the European Hematology Association (EHA) and also as a member of the Scientific Committee on Bone Marrow Failure of the American Society of Hematology (ASH). Both…
July 18, 2019
NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Making cancer stem cells visible to the immune system - New results may enable innovative treatment concept against leukemia (New publication in Nature)

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for natural killer (NK) cells. This protective mechanism can be tricked with drugs. The exciting finding has been made by colleagues of the Trumpp team from…
July 11, 2019
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A new tool to study hematopoiesis in detail: Optimized multicolor immunofluorescence panel differentiating major steps of blood development published in Cytometry (OMIP‐059)

The mammalian blood system is one of the best-researched hierarchical stem cell systems. It is also a main focus of the research in HI-STEM as it is a key for the understanding of the development of hematopoietic stem cells (HSCs) and the catastrophic…
June 05, 2019

Her Honour Lieutenant Governor of Ontario Elizabeth Dowdeswell visits HI-STEM

On June 4th, as part of her visit of the DKFZ, her Honour Lieutenant Governor of Ontario Elizabeth Dowdeswel (@LGLizDowdeswell) visited the HI-STEM Lab. As part of her tour she showed great interest in our research on the role of stem cells in cancer.…
April 11, 2019

International Symposium FOR 2033: The Hematopoietic Niches; Munich, May 10th-11th, 2019

Marieke Essers is co-organizing the International Symposium "The Hematopoietic Niches" together with her colleagues from the DFG-funded NicHem Research Group. For further details and the full program please see the conference website.
April 02, 2019
The HI-STEM Founding Team celebrates ten years of successful cooperation: Friedrich von Bohlen, Managing Director dievini Hopp BioTech Holding, Josef Puchta, Administrative Director DKFZ, Heike Bauer, Head Dietmar Hopp Stiftung, Dietmar Hopp Founder and Managing Director Dietmar Hopp Foundation, Andreas Trumpp, HI-STEM Managing Director, Michael Baumann, DKFZ Managing Director, Christof Hettich, Co-Managing Director dievini Hopp BioTech Holding (from left to right) | © Stefan Hebling

Ten Years of HI-STEM – Founding Team Celebrates Successful Partnership on Cancer Stem Cell Research

Ten years ago, HI-STEM, the Heidelberg Institute for Stem Cell Technology and Experimental Medicine, started its work within the newly renovated labs of the German Cancer Research Center (DKFZ). On the occasion of this anniversary, the founders have drawn a…
February 14, 2019

The long non-coding RNA Meg3 is highly and specifically expressed in HSCs, but surprisingly is not required for hematopoiesis – New Publication in Scientific Reports

In this study, we have addressed the role of the imprinted long non-coding RNA (lncRNA) Meg3 and its associated miRNA cluster for adult hematopoietic stem cell (HSC) function. Meg3 is highly and specifically expressed in adult HSCs, but not in progenitor or…
February 10, 2019

Cell-culture Medium for pancreatic cancer cells co-developed by Miltenyi Biotec and HI-STEM now on sale

Based on an ongoing collaboration between HI-STEM and the German Biotech Company Miltenyi Biotec GmbH, our cell-culture medium for tumor cells from the pancreas is now available for sale at Miltenyi. The medium is an improved version of the one described in…
February 07, 2019

Congratutions to Dr. Mattia Falcone for sucessfullly defending his PhD Thesis on BCAT1 in Leukemia!

Congratulazioni Mattia! Want to read more on his work? Here is the main paper of his thesis:
February 04, 2019

HI-STEM lab visited by Tino Sorge, Member of the German Bundestag

Today, Tino Sorge has visited the HI-STEM lab as part of the 1st German Cancer Research Congress (GCRC). Andreas Trumpp took the opportunity to explain how modern cancer research at the HI-STEM lab and the DKFZis pivotal for the development of innovative and…
December 20, 2018

Human blood cells can be directly reprogrammed into neural stem cells - New Publication in Cell Stem Cell

In the study, which was led by HI-STEM postdoc Marc Thier, we have succeeded for the first time to directly reprogram human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the…
December 09, 2018
Andreas Trumpp together with Minister of Science and Education Theresia Bauer

Prestigious award for Andreas Trumpp

The State Research Prize for Applied Research (Landesforschungspreis) of Baden-Württemberg 2018 is awarded to Andreas Trumpp. The Minister for Science, Research and Art Theresia Bauer presented the award, which includes a prize money of 100.000 Euro, during a…
November 30, 2018

Marieke Essers receives the Prize of the Berlin-Brandenburg Academy of Sciences and Humanities

The Berlin-Brandenburg Acadamy of Sciences and Humanities (BBAW) is honoring Marieke Essers pioneering research work on hematopoietic stem cells and their activation during stress conditions such as inflammation. The award is donated by the Monika Kutzner…
September 19, 2018
Participants of the 2018 F. C. Behr-Symposium

International Behr-Symposium on Stem Cells and Cancer

From September 16-19, 2018, HI-STEM, together with the DKFZ and the Heidelberg University Hospital, was hosting the 10th International Heinrich F.C. Behr-Symposium on Stem Cells and Cancer. The conference featured talks by over 25 invited international…
September 19, 2018

HI STEM researchers show link between stress signaling and chemotherapy resistant metastasis in breast cancer

In collaboration with physicians in Heidelberg and Mannheim, the group of Thordur Oskarsson at HI-STEM and DKFZ published a research paper in EMBO Molecular Medicine on September 6, 2018, ahead of print. The first author Jacob Insua-Rodríguez, a member of the…
July 30, 2018
Andreas Trumpp

Andreas Trumpp elected as Board Member of the European Association for Cancer Research (EACR)

The European Association for Cancer Research (EACR) is Europe’s professional membership association for those working and studying in cancer research, with more than 10,000 members worldwide. Its mission is “The advancement of cancer research for the public…
July 20, 2018

HI-STEM Teams Win Gold and Silver at the DKFZ’s Sommerfest Cup!

HI-STEM Researchers do not only know how to deal with stem cells but also how to score as was shown during the 2018 DKFZ Summer Party. Two mixed teams started both defeating all other teams leading to a double victory for out two teams!

New Review in Cell Stem Cell: Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

May 07, 2018 3985
Classically, stem and progenitor populations have been considered discrete homogeneous…

Double sucess for HI-STEM researchers Simon Haas and Simon Raffel

Apr 04, 2018 8279
Two awards at once, both carrying high monetary prizes, go to two HI-STEM members: Simon…

Ten years of successful research on cancer stem cells at HI-STEM – Third funding period announced!

Mar 21, 2018 1500
Since its installation in 2008, HI-STEM can look back at ten years of successful…

HI-STEM participates in UniStem Day 2018

Mar 16, 2018 1176
Today, over 200 high-school students have visited the DKFZ to learn more about stem cells…

Marieke Essers receives the Chica and Heinz Schaller Research Award

Feb 09, 2018 3407
On February 5, 2018, the Chica and Heinz Schaller Research Award were presented to…

Regulating Stem Cell Function from Long Distances: HI-STEM Team and Colleagues Describe New Layers of Myc Regulation in Nature

Jan 23, 2018 1668
In the publication, which appeared online at Nature.comon January 17, 2018, the…

Nature Paper on BCAT1 overexpression in leukemia featured in Cancer Discovery

Nov 23, 2017 1678
Our recent Nature paper on BCAT1 overexpression in leukemia has been featured in the…

Misregulated protein breakdown promotes leukemias and brain cancer – new HI-STEM Publication online in Nature

Nov 10, 2017 3370
In the new paper published online at nature.com on November 8, we describe how high…

HI-STEM Mini-Symposium

Aug 17, 2017 1869
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HI-STEM Mini-Symposium on Normal and Malignant Hematopoietic Stem Cells on August 28 The…

Major honor: Prince William and Duchess Catherine have visited the DKFZ and HI-STEM labs

Jul 25, 2017 2399
Prince William and his wife, Duchess Catherine, visited the HI-STEM laboratory on July 20, 2017
As part of their official visit to Germany, Prince William and his wife, Duchess…

HI-STEM group leader receives David B. Frohnmayer Award.

Jan 27, 2017 2974
Dr. Michael Milsom was recently awarded the 2016 Fanconi Anemia Research Fund’s David B.…