Solid Tumors, Metastasis & Therapy Resistance

Hematopoietic Stem Cells and Leukemia

Stem Cells and Tumor Microenvironment

HI-STEM Group Leaders

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Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B & Trumpp A. (2017). BCAT1 restrictsαKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Nature 551(7680): 384-388 doi: 10.1038/nature24294

Links and further information

Pubmed | Read at Publisher
DKFZ Press Release (englisch)
DKFZ Pressemitteilung (German)