Solid Tumors, Metastasis & Therapy Resistance

Hematopoietic Stem Cells and Leukemia

Stem Cells and Tumor Microenvironment

HI-STEM Group Leaders

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Highlight Publications

March 22, 2016

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma (Nature Medicine, 2016)

Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel, V., Klaus, B., Nadler, W., Rosli, C., Lutz, C., Kulke, M., Engelhardt, J., Zickgraf, F.M., Espinosa, O., Schlesner, M., Jiang, X., Kopp-Schneider, A., Neuhaus, P., Bahra,…
September 02, 2014

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients (Oncotarget, 2014)

Baccelli, I., Stenzinger, A., Vogel, V., Pfitzner, B.M., Klein, C., Wallwiener, M., Scharpff, M., Saini, M., Holland-Letz, T., Sinn, H.P., Schneeweiss, A., Denkert, C., Weichert, W., & Trumpp, A. (2014). Co-expression of MET and CD47 is a novel prognosticator…
April 21, 2013

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay (Nature Biotechnology, 2013)

Baccelli, I., Schneeweiss, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., Klein, C., Saini, M., Bauerle, T., Wallwiener, M., Holland-Letz, T., Hofner, T., Sprick, M., Scharpff, M., Marme, F., Sinn, H.P., Pantel, K., Weichert, W., & Trumpp, A.…

All Publications

Aloia, A., Petrova, E., Tomiuk, S., Bissels, U., Deas, O., Saini, M., Zickgraf, F.M., Wagner, S., Spaich, S., Sutterlin, M., Schneeweiss, A., Reitberger, M., Ruberg, S., Gerstmayer, B., Agorku, D., Knobel, S., Terranegra, A., Falleni, M., Soldati, L., Sprick, M.R., Trumpp, A., Judde, J.G., Bosio, A., Cairo, S., & Hardt, O. (2015). The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features. Breast Cancer Research, 17. 10.1186/s13058-015-0652-6

Baccelli, I., Schneeweiss, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., Klein, C., Saini, M., Bauerle, T., Wallwiener, M., Holland-Letz, T., Hofner, T., Sprick, M., Scharpff, M., Marme, F., Sinn, H.P., Pantel, K., Weichert, W., & Trumpp, A. (2013). Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol, 31(6), 539-544. 10.1038/nbt.2576

Berger, A.K., Singh, H.M., Werft, W., Muckenhuber, A., Sprick, M.R., Trumpp, A., Weichert, W., Jager, D., & Springfeld, C. (2017). High prevalence of incidental and symptomatic venous thromboembolic events in patients with advanced pancreatic cancer under palliative chemotherapy: A retrospective cohort study. Pancreatology. 10.1016/j.pan.2017.04.012

Deutsch, T.M., Riethdorf, S., Nees, J., Hartkopf, A.D., Schonfisch, B., Domschke, C., Sprick, M.R., Schutz, F., Brucker, S.Y., Stefanovic, S., Sohn, C., Pantel, K., Trumpp, A., Schneeweiss, A., & Wallwiener, M. (2016). Impact of apoptotic circulating tumor cells (aCTC) in metastatic breast cancer. Breast Cancer Res Treat., 160(2), 277-290. 10.1007/s10549-016-3997-3

Dietlein, F., Kalb, B., Jokic, M., Noll, E.M., Strong, A., Tharun, L., Ozretic, L., Kunstlinger, H., Kambartel, K., Randerath, W.J., Jungst, C., Schmitt, A., Torgovnick, A., Richters, A., Rauh, D., Siedek, F., Persigehl, T., Mauch, C., Bartkova, J., Bradley, A., Sprick, M.R., Trumpp, A., Rad, R., Saur, D., Bartek, J., Wolf, J., Buttner, R., Thomas, R.K., & Reinhardt, H.C. (2015). A Synergistic Interaction between Chk1-and MK2 Inhibitors in KRAS-Mutant Cancer. Cell, 162(1), 146-159. 10.1016/j.cell.2015.05.053

Djurec, M., Grana, O., Lee, A., Troule, K., Espinet, E., Cabras, L., Navas, C., Blasco, M.T., Martin-Diaz, L., Burdiel, M., Li, J., Liu, Z.Q., Vallespinos, M., Sanchez-Bueno, F., Sprick, M.R., Trumpp, A., Sainz, B., Al-Shahrour, F., Rabadan, R., Guerra, C., & Barbacid, M. (2018). Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors. Proceedings of the National Academy of Sciences of the United States of America, 115(6), E1147-E1156. 10.1073/pnas.1717802115

Hofner, T., Macher-Goeppinger, S., Klein, C., Rigo-Watermeier, T., Eisen, C., Pahernik, S., Hohenfellner, M., Trumpp, A., & Sprick, M.R. (2013). Development and Characteristics of Preclinical Experimental Models for the Research of Rare Neuroendocrine Bladder Cancer. Journal of Urology, 190(6), 2263-2270. 10.1016/j.juro.2013.06.053

Hofner, T., Macher-Goeppinger, S., Klein, C., Schillert, A., Eisen, C., Wagner, S., Rigo-Watermeier, T., Baccelli, I., Vogel, V., Trumpp, A., & Sprick, M.R. (2014). Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy. Urologic Oncology-Seminars and Original Investigations, 32(5), 678-686. 10.1016/j.urolonc.2014.01.001

Hofner, T., Eisen, C., Klein, C., Rigo-Watermeier, T., Goeppinger, S.M., Jauch, A., Schoell, B., Vogel, V., Noll, E., Weichert, W., Baccelli, I., Schillert, A., Wagner, S., Pahernik, S., Sprick, M.R., & Trumpp, A. (2015). Defined Conditions for the Isolation and Expansion of Basal Prostate Progenitor Cells of Mouse and Human Origin. Stem Cell Reports, 4(3), 503-518. 10.1016/j.stemcr.2015.01.015

Hofner, T., Klein, C., Eisen, C., Rigo-Watermeier, T., Haferkamp, A., Trumpp, A., & Sprick, M.R. (2016). The Influence of Prostatic Anatomy and Neurotrophins on Basal Prostate Epithelial Progenitor Cells. Prostate, 76(1), 114-121. 10.1002/pros.23109

Jabs, J., Zickgraf, F.M., Park, J., Wagner, S., Jiang, X.Q., Jechow, K., Kleinheinz, K., Toprak, U.H., Schneider, M.A., Meister, M., Spaich, S., Sutterlin, M., Schlesner, M., Trumpp, A., Sprick, M., Eils, R., & Conrad, C. (2017). Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. Molecular Systems Biology, 13(11). 10.15252/msb.20177697

Jauch, S.F., Riethdorf, S., Sprick, M.R., Schutz, F., Schonfisch, B., Brucker, S.Y., Deutsch, T.M., Nees, J., Saini, M., Becker, L.M., Burwinkel, B., Sinn, P., Marme, F., Pantel, K., Jager, D., Sohn, C., Trumpp, A., Wallwiener, M., & Schneeweiss, A. (2018). Sustained prognostic impact of circulating tumor cell status and kinetics upon further progression of metastatic breast cancer. Breast Cancer Res Treat. 10.1007/s10549-018-4972-y

Kuhlmann, L., Nadler, W.M., Kerner, A., Hanke, S.A., Noll, E.M., Eisen, C., Espinet, E., Vogel, V., Trumpp, A., Sprick, M.R., & Roesli, C.P. (2017). Identification and Validation of Novel Subtype-Specific Protein Biomarkers in Pancreatic Ductal Adenocarcinoma. Pancreas, 46(3), 311-322. 10.1097/MPA.0000000000000743

Lorentzen, A., Becker, P.F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M.J., Geist, F., Seubert, B., Ringelhan, M., Mihic-Probst, D., Esser, K., Roblek, M., Kuehne, F., Bianco, G., O'Connor, T., Muller, Q., Schuck, K., Lange, S., Hartmann, D., Spaich, S., Gross, O., Utikal, J., Haferkamp, S., Sprick, M.R., Damle-Vartak, A., Hapfelmeier, A., Huser, N., Protzer, U., Trumpp, A., Saur, D., Vartak, N., Klein, C.A., Polzer, B., Borsig, L., & Heikenwalder, M. (2018). Single cell polarity in liquid phase facilitates tumour metastasis. Nature Communications, 9. /10.1038/s41467-018-03139-6

Muckenhuber, A., Berger, A.K., Schlitter, A.M., Steiger, K., Konukiewitz, B., Trumpp, A., Eils, R., Werner, J., Friess, H., Esposito, I., Kloppel, G., Ceyhan, G.O., Jesinghaus, M., Denkert, C., Bahra, M., Stenzinger, A., Sprick, M.R., Jager, D., Springfeld, C., & Weichert, W. (2018). Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response. Clinical Cancer Research, 24(2), 351-359. 10.1158/1078-0432.ccr-17-2180

Muzumdar, M.D., Chen, P.Y., Dorans, K.J., Chung, K.M., Bhutkar, A., Hong, E., Noll, E.M., Sprick, M.R., Trumpp, A., & Jacks, T. (2017). Survival of pancreatic cancer cells lacking KRAS function. Nature Communications, 8. 10.1038/s41467-017-00942-5

Neugebauer, J., Zickgraf, F.M., Park, J., Wagner, S., Jiang, X., Jechow, K., Kleinheinz, K., Toprak, U.H., Schneider, M.A., Meister, M., Spaich, S., Suetterlin, M., Schlesner, M., Trumpp, A., Sprick, M., Eils, R., & Conrad, C. (2017). Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations. bioRxiv. 10.1101/124446

Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel, V., Klaus, B., Nadler, W., Rosli, C., Lutz, C., Kulke, M., Engelhardt, J., Zickgraf, F.M., Espinosa, O., Schlesner, M., Jiang, X.Q., Kopp-Schneider, A., Neuhaus, P., Bahra, M., Sinn, B.V., Eils, R., Giese, N.A., Hackert, T., Strobel, O., Werner, J., Buchler, M.W., Weichert, W., Trumpp, A., & Sprick, M.R. (2016). CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nature Medicine, 22(3), 278-287. 10.1038/nm.4038

Noll, E.M., Trumpp, A., & Sprick, M.R. (2016). Challenges and opportunities of CYP3A5 as novel drug target in pancreatic cancer subtypes. Translational Cancer Research, S930-S931. 10.21037/tcr.2016.10.59

Poschke, I., Faryna, M., Bergmann, F., Flossdorf, M., Lauenstein, C., Hermes, J., Hinz, U., Hank, T., Ehrenberg, R., Volkmar, M., Loewer, M., Glimm, H., Hackert, T., Sprick, M.R., Hofer, T., Trumpp, A., Halama, N., Hassel, J.C., Strobel, O., Buchler, M., Sahin, U., & Offringa, R. (2016). Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma. Oncoimmunology, 5(12), e1240859. 10.1080/2162402X.2016.1240859

Schillert, A., Trumpp, A., & Sprick, M.R. (2013). Label retaining cells in cancer - The dormant root of evil? Cancer Letters, 341(1), 73-79. 10.1016/j.canlet.2013.04.019

Teodorczyk, M., Kleber, S., Wollny, D., Sefrin, J.P., Aykut, B., Mateos, A., Herhaus, P., Sancho-Martinez, I., Hill, O., Gieffers, C., Sykora, J., Weichert, W., Eisen, C., Trumpp, A., Sprick, M.R., Bergmann, F., Welsch, T., & Martin-Villalba, A. (2015). CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma. Cell Death and Differentiation, 22(7), 1192-1202. 10.1038/cdd.2014.217

Wallwiener, M., Riethdorf, S., Hartkopf, D., Modugno, C., Nees, J., Madhavan, D., Sprick, M.R., Schott, S., Domschke, C., Baccelli, I., Schonfisch, B., Burwinkel, B., Marme, F., Heil, J., Sohn, C., Pantel, K., Trumpp, A., & Schneeweiss, A. (2014). Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients. BMC Cancer, 14. 10.1186/1471-2407-14-512