November 05, 2019
Source: Saçma, M., Pospiech, J., Bogeska, R. et al. Haematopoietic stem cells in perisinusoidal niches are protected from ageing. Nat Cell Biol (2019) doi:10.1038/s41556-019-0418-y

Haematopoietic stem cells in perisinusoidal niches are protected from ageing (Nature, 2019)

Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., Soller, K., Marka, G., Vollmer, A., Karns, R., Cabezas-Wallscheid, N., Trumpp, A., Méndez-Ferrer, S., Milsom, M.D., Mulaw, M.A., Geiger, H., & Florian, M.C. (2019). Haematopoietic stem…
July 18, 2019
NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, 2019)

Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J.R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B.R., Caligiuri, M.A.,…
July 07, 2019

Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel (Cytometry A, 2019)

Eich, M., Trumpp, A., & Schmitt, S. (2019). OMIP-059: Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel. Cytometry A. doi:…
May 08, 2019
Meningioma heatmap

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma (Acta Neuropathologica, 2019)

Paramasivam, N.*, Hubschmann, D.*, Toprak, U.H., Ishaque, N., Neidert, M., Schrimpf, D., Stichel, D., Reuss, D., Sievers, P., Reinhardt, A., Wefers, A.K., Jones, D.T.W., Gu, Z., Werner, J., Uhrig, S., Wirsching, H.G., Schick, M., Bewerunge-Hudler, M., Beck,…
April 09, 2019
Chordoma Research

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma (Nature Communications, 2019)

Groschel, S.*, Hubschmann, D.*, Raimondi, F., Horak, P., Warsow, G., Frohlich, M., Klink, B., Gieldon, L., Hutter, B., Kleinheinz, K., Bonekamp, D., Marschal, O., Chudasama, P., Mika, J., Groth, M., Uhrig, S., Kramer, S., Heining, C., Heilig, C.E., Richter,…
April 02, 2019

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma (Nature Communications, 2019)

Lopez, C.*, Kleinheinz, K.*, Aukema, S.M.*, Rohde, M.*, Bernhart, S.H.*, Hübschmann, D.*, Wagener, R., Toprak, U.H., Raimondi, F., Kreuz, M., Waszak, S.M., Huang, Z., Sieverling, L., Paramasivam, N., Seufert, J., Sungalee, S., Russell, R.B., Bausinger, J.,…
February 14, 2019

The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells (Scientific Reports, 2019)

Sommerkamp, P., Renders, S., Ladel, L., Hotz-Wagenblatt, A., Schönberger, K., Zeisberger, P., Przybylla, A., Sohn, M., Zhou, Y., Klibanski, A., Cabezas-Wallscheid, N.@, & Trumpp, A.@ (2019). The long non-coding RNA Meg3 is dispensable for hematopoietic stem…
December 20, 2018

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells (Cell Stem Cell, 2019)

Thier, M.C., Hommerding, O., Panten, J., Pinna, R., Garcia-Gonzalez, D., Berger, T., Worsdorfer, P., Assenov, Y., Scognamiglio, R., Przybylla, A., Kaschutnig, P., Becker, L., Milsom, M.D., Jauch, A., Utikal, J., Herrmann, C., Monyer, H., Edenhofer, F., &…
September 06, 2018

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis (EMBO Molecular Medicine, 2018)

Insua-Rodríguez J, Pein M, Hongu T, Meier J, Descot A, Lowy CM, De Braekeleer E, Sinn HP, Spaich S, Sütterlin M, Schneeweiss A, Oskarsson T (2018). "Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis" EMBO…
July 05, 2018

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)

Haas, S., Trumpp, A., & Milsom, M.D. (2018). Causes and Consequences of Hematopoietic Stem Cell Heterogeneity. Cell Stem Cell, 22(5), 627-638. doi: 10.1016/j.stem.2018.04.003
January 17, 2018

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (Nature, 2018)

Bahr, C.*, von Paleske, L.*, Uslu, V.V.*, Remeseiro, S., Takayama, N., Ng, S.W., Murison, A., Langenfeld, K., Petretich, M., Scognamiglio, R., Zeisberger, P., Benk, A.S., Amit, I., Zandstra, P.W., Lupien, M., Dick, J.E., Trumpp, A.@, & Spitz, F.@ (2018). A…
November 10, 2017

BCAT1 restrictsαKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Nature, 2017)

Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L., Poschet, G., Nonnenmacher, Y., Barnert, A., Bahr, C., Zeisberger, P., Przybylla, A., Sohn, M., Tonjes, M., Erez, A., Adler, L., Jensen, P., Scholl, C., Frohling, S.,…
June 13, 2017

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo (Cell Reports, 2017)

Hirche, C., Frenz, T., Haas, S.F., Döring, M., Borst, K., Tegtmeyer, P.-K., Brizic, I., Jordan, S., Keyser, K., & Chhatbar, C. (2017). Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells…
May 18, 2017

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy (Cell, 2017)

Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F.B., Pastor-Flores, D., Roma, L.P., Renders, S., Zeisberger, P., Przybylla, A., Schonberger, K., Scognamiglio, R., Altamura, S., Florian, C.M., Fawaz, M., Vonficht,…
March 20, 2017

Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)

Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche, C., Lutz, C., Buss, E.C., Nowak, D., Boch, T., Hofmann, W.K., Ho, A.D., Huber, W., Trumpp, A.@, Essers, M.A.@, & Steinmetz, L.M.@ (2017). Human haematopoietic stem cell…
October 15, 2016

IFN alpha-mediated remodeling of endothelial cells in the bone marrow niche (Haematologica, 2017)

Prendergast, A.M., Kuck, A., van Essen, M., Haas, S., Blaszkiewicz, S., & Essers, M.A.G. (2017). IFN alpha-mediated remodeling of endothelial cells in the bone marrow niche. Haematologica, 102(3), 445-453. doi: 10.3324/haematol.2016.151209

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma (Nature Medicine, 2016)

Mar 22, 2016
Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel,…

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause (Cell, 2016)

Feb 16, 2016
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A.,…

Inflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors (Cell Stem Cell, 2015)

Oct 01, 2015
Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S.,…

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells (Nature, 2015)

Apr 23, 2015
Walter, D., Lier, A., Geiselhart, A., Thalheimer, F.B., Huntscha, S., Sobotta, M.C.,…

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients (Oncotarget, 2014)

Sep 02, 2014
Baccelli, I., Stenzinger, A., Vogel, V., Pfitzner, B.M., Klein, C., Wallwiener, M.,…

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit (Cell Stem Cell, 2014)

Jun 05, 2014
Medyouf, H., Mossner, M., Jann, J.C., Nolte, F., Raffel, S., Herrmann, C., Lier, A.,…

Awakening dormant haematopoietic stem cells (Nature Reviews Immunology, 2010)

Mar 01, 2010
Trumpp, A., Essers, M., & Wilson, A. (2010). Awakening dormant haematopoietic stem cells.…

IFNalpha activates dormant haematopoietic stem cells in vivo (Nature, 2009)

Apr 16, 2009
Essers, M.A., Offner, S., Blanco-Bose, W.E., Waibler, Z., Kalinke, U., Duchosal, M.A., &…

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair (Cell, 2008)

Dec 12, 2008
Wilson, A., Laurenti, E., Oser, G., van der Wath, R.C., Blanco-Bose, W., Jaworski, M.,…

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity (Cell Stem Cell, 2008)

Dec 04, 2008
Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Bose, W.E., Ehninger,…

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation (Genes and Development, 2004)

Sep 13, 2004
Wilson, A., Murphy, M.J., Oskarsson, T., Kaloulis, K., Bettess, M.D., Oser, G.M., Pasche,…

c-Myc regulates mammalian body size by controlling cell number but not cell size (Nature, 2001)

Dec 13, 2001
Trumpp, A., Refaeli, Y., Oskarsson, T., Gasser, S., Murphy, M., Martin, G.R., & Bishop,…