Research Group Experimental Hematology

Mick Milsom
Senior Group Leader

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  • Ackermann, M., Haake, K., Kempf, H., Kaschutnig, P., Weiss, A.C., Nguyen, A.H.H., Abeln, M., Merkert, S., Kuhnel, M.P., Hartmann, D., Jonigk, D., Thum, T., Kispert, A., Milsom, M.D., & Lachmann, N. (2020). A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification. Haematologica. doi: 10.3324/haematol.2019.228064
  • Morcos, M.N.F., Zerjatke, T., Glauche, I., Munz, C.M., Ge, Y., Petzold, A., Reinhardt, S., Dahl, A., Anstee, N.S., Bogeska, R., Milsom, M.D., Sawen, P., Wan, H., Bryder, D., Roers, A., & Gerbaulet, A. (2020). Continuous mitotic activity of primitive hematopoietic stem cells in adult mice. J Exp Med, 217(6). doi: 10.1084/jem.20191284
  • Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., Soller, K., Marka, G., Vollmer, A., Karns, R., Cabezas-Wallscheid, N., Trumpp, A., Méndez-Ferrer, S., Milsom, M.D., Mulaw, M.A., Geiger, H., & Florian, M.C. (2019). Haematopoietic stem cells in perisinusoidal niches are protected from ageing. Nature Cell Biology. doi: 10.1038/s41556-019-0418-y
  • Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, A.M., Schnell, A., Hexel, K., Santarella-Mellwig, R., Blaszkiewicz, S., Kuck, A., Geiger, H., Milsom, M.D., Steinmetz, L.M., Schroeder, T., Trumpp, A., Krijgsveld, J., & Essers, M.A. (2015). Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell, 17(4), 422-434. doi: 10.1016/j.stem.2015.07.007
  • Kaschutnig, P., Bogeska, R., Walter, D., Lier, A., Huntscha, S., & Milsom, M.D. (2015). The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells. Cell Cycle, 14(17), 2734-2742. doi: 10.1080/15384101.2015.1068474
  • Walter, D., Lier, A., Geiselhart, A., Thalheimer, F.B., Huntscha, S., Sobotta, M.C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., Muedder, K., Klein, C., Jauch, A., Schroeder, T., Geiger, H., Dick, T.P., Holland-Letz, T., Schmezer, P., Lane, S.W., Rieger, M.A., Essers, M.A., Williams, D.A., Trumpp, A., & Milsom, M.D. (2015). Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature, 520(7548), 549-552. doi: 10.1038/nature14131
  • Cabezas-Wallscheid, N., Klimmeck, D., Hansson, J., Lipka, D.B., Reyes, A., Wang, Q., Weichenhan, D., Lier, A., von Paleske, L., Renders, S., Wunsche, P., Zeisberger, P., Brocks, D., Gu, L., Herrmann, C., Haas, S., Essers, M.A.G., Brors, B., Eils, R., Huber, W., Milsom, M.D., Plass, C., Krijgsveld, J., & Trumpp, A. (2014). Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell, 15(4), 507-522. doi: 10.1016/j.stem.2014.07.005
  • Lipka, D.B., Wang, Q., Cabezas-Wallscheid, N., Klimmeck, D., Weichenhan, D., Herrmann, C., Lier, A., Brocks, D., von Paleske, L., Renders, S., Wunsche, P., Zeisberger, P., Gu, L., Haas, S., Essers, M.A., Brors, B., Eils, R., Trumpp, A.§, Milsom, M.D.§, & Plass, C. (2014). Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing. Cell Cycle, 13(22), 3476-3487. doi: 10.4161/15384101.2014.973334 §Shared senior authorship
  • Placke, T., Faber, K., Nonami, A., Putwain, S.L., Salih, H.R., Heidel, F.H., Kramer, A., Root, D.E., Barbie, D.A., Krivtsov, A.V., Armstrong, S.A., Hahn, W.C., Huntly, B.J., Sykes, S.M., Milsom, M.D., Scholl, C., & Frohling, S. (2014). Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood, 124(1), 13-23. doi: 10.1182/blood-2014-02-558114