Research Group Metastatic Niches

Thordur Oskarsson
Group Leader

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Highlight Publications

March 20, 2020
Lung metastasis in a breast cancer patient: the arrows indicate fibroblasts (brown) that communicate with metastatic cancer cells. Cell nuclei are stained blue. © Oskarsson, DKFZ/HI-STEM

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs (Nature Communications, 2020)

Pein, M., Insua-Rodríguez, J., Hongu, T., Riedel, A., Meier, J., Wiedmann, L., Decker, K., Essers, M. A. G., Sinn, H. P., Spaich, S., Sutterlin, M., Schneeweiss, A., Trumpp, A. and Oskarsson, T. (2020). Metastasis-initiating cells induce and exploit a…
September 06, 2018

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis (EMBO Molecular Medicine, 2018)

Insua-Rodríguez J, Pein M, Hongu T, Meier J, Descot A, Lowy CM, De Braekeleer E, Sinn HP, Spaich S, Sütterlin M, Schneeweiss A, Oskarsson T (2018). "Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis" EMBO…

Other Selected Publications

  • Acharyya, S., Oskarsson, T., Vanharanta, S., Malladi, S., Kim, J., Morris, P.G., Manova-Todorova, K., Leversha, M., Hogg, N., & Seshan, V.E. (2012). A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell, 150(1), 165-178. doi: 10.1016/j.cell.2012.04.042

  • Insua-Rodriguez, J., & Oskarsson, T. (2016). The extracellular matrix in breast cancer. Advanced Drug Delivery Reviews, 97, 41-55. doi: 10.1016/j.addr.2015.12.017

  • Insua‐Rodríguez, J., Pein, M., Hongu, T., Meier, J., Descot, A., Lowy, C.M., De Braekeleer, E., Sinn, H.P., Spaich, S., & Sütterlin, M. (2018). Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis. EMBO molecular medicine, e9003. doi: 10.15252/emmm.201809003

  • Kim, M.-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X.H.-F., Norton, L., & Massagué, J. (2009). Tumor self-seeding by circulating cancer cells. Cell, 139(7), 1315-1326. doi: 10.1016/j.cell.2009.11.025

  • Oskarsson, T., Nagorny, P., Krauss, I.J., Perez, L., Mandal, M., Yang, G., Ouerfelli, O., Xiao, D., Moore, M.A., & Massagué, J. (2010). Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. Journal of the American Chemical Society, 132(9), 3224-3228. doi: 10.1021/ja9101503

  • Oskarsson, T., Acharyya, S., Zhang, X.H., Vanharanta, S., Tavazoie, S.F., Morris, P.G., Downey, R.J., Manova-Todorova, K., Brogi, E., & Massagué, J. (2011). Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nature medicine, 17(7), 867. doi: 10.1038/nm.2379

  • Oskarsson, T., Batlle, E., & Massagué, J. (2014). Metastatic stem cells: sources, niches, and vital pathways. Cell stem cell, 14(3), 306-321. doi: 10.1016/j.stem.2014.02.002