Highlight Publications
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs (Nature Cancer, 2022)
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs (Nature Communications, 2020)
Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis (EMBO Molecular Medicine, 2018)
Other Selected Publications
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Acharyya, S., Oskarsson, T., Vanharanta, S., Malladi, S., Kim, J., Morris, P.G., Manova-Todorova, K., Leversha, M., Hogg, N., & Seshan, V.E. (2012). A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell, 150(1), 165-178. doi: 10.1016/j.cell.2012.04.042
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Insua-Rodriguez, J., & Oskarsson, T. (2016). The extracellular matrix in breast cancer. Advanced Drug Delivery Reviews, 97, 41-55. doi: 10.1016/j.addr.2015.12.017
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Insua‐Rodríguez, J., Pein, M., Hongu, T., Meier, J., Descot, A., Lowy, C.M., De Braekeleer, E., Sinn, H.P., Spaich, S., & Sütterlin, M. (2018). Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis. EMBO molecular medicine, e9003. doi: 10.15252/emmm.201809003
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Kim, M.-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X.H.-F., Norton, L., & Massagué, J. (2009). Tumor self-seeding by circulating cancer cells. Cell, 139(7), 1315-1326. doi: 10.1016/j.cell.2009.11.025
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Oskarsson, T., Nagorny, P., Krauss, I.J., Perez, L., Mandal, M., Yang, G., Ouerfelli, O., Xiao, D., Moore, M.A., & Massagué, J. (2010). Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. Journal of the American Chemical Society, 132(9), 3224-3228. doi: 10.1021/ja9101503
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Oskarsson, T., Acharyya, S., Zhang, X.H., Vanharanta, S., Tavazoie, S.F., Morris, P.G., Downey, R.J., Manova-Todorova, K., Brogi, E., & Massagué, J. (2011). Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nature medicine, 17(7), 867. doi: 10.1038/nm.2379
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Oskarsson, T., Batlle, E., & Massagué, J. (2014). Metastatic stem cells: sources, niches, and vital pathways. Cell stem cell, 14(3), 306-321. doi: 10.1016/j.stem.2014.02.002