Research Group Normal and Malignant Stem Cells

Andreas Trumpp
Group Leader

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I. Highlight Publications

July 18, 2019
NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, 2019)

Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J.R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B.R., Caligiuri, M.A.,…
February 14, 2019

The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells (Scientific Reports, 2019)

Sommerkamp, P., Renders, S., Ladel, L., Hotz-Wagenblatt, A., Schönberger, K., Zeisberger, P., Przybylla, A., Sohn, M., Zhou, Y., Klibanski, A., Cabezas-Wallscheid, N.@, & Trumpp, A.@ (2019). The long non-coding RNA Meg3 is dispensable for hematopoietic stem…
December 20, 2018

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells (Cell Stem Cell, 2019)

Thier, M.C., Hommerding, O., Panten, J., Pinna, R., Garcia-Gonzalez, D., Berger, T., Worsdorfer, P., Assenov, Y., Scognamiglio, R., Przybylla, A., Kaschutnig, P., Becker, L., Milsom, M.D., Jauch, A., Utikal, J., Herrmann, C., Monyer, H., Edenhofer, F., &…
January 17, 2018

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (Nature, 2018)

Bahr, C.*, von Paleske, L.*, Uslu, V.V.*, Remeseiro, S., Takayama, N., Ng, S.W., Murison, A., Langenfeld, K., Petretich, M., Scognamiglio, R., Zeisberger, P., Benk, A.S., Amit, I., Zandstra, P.W., Lupien, M., Dick, J.E., Trumpp, A.@, & Spitz, F.@ (2018). A…
November 10, 2017

BCAT1 restrictsαKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Nature, 2017)

Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L., Poschet, G., Nonnenmacher, Y., Barnert, A., Bahr, C., Zeisberger, P., Przybylla, A., Sohn, M., Tonjes, M., Erez, A., Adler, L., Jensen, P., Scholl, C., Frohling, S.,…
May 18, 2017

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy (Cell, 2017)

Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F.B., Pastor-Flores, D., Roma, L.P., Renders, S., Zeisberger, P., Przybylla, A., Schonberger, K., Scognamiglio, R., Altamura, S., Florian, C.M., Fawaz, M., Vonficht,…

Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)

Mar 20, 2017
Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche,…

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause (Cell, 2016)

Feb 16, 2016
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A.,…

Awakening dormant haematopoietic stem cells (Nature Reviews Immunology, 2010)

Mar 01, 2010
Trumpp, A., Essers, M., & Wilson, A. (2010). Awakening dormant haematopoietic stem cells.…

IFNalpha activates dormant haematopoietic stem cells in vivo (Nature, 2009)

Apr 16, 2009
Essers, M.A., Offner, S., Blanco-Bose, W.E., Waibler, Z., Kalinke, U., Duchosal, M.A., &…

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair (Cell, 2008)

Dec 12, 2008
Wilson, A., Laurenti, E., Oser, G., van der Wath, R.C., Blanco-Bose, W., Jaworski, M.,…

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity (Cell Stem Cell, 2008)

Dec 04, 2008
Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Bose, W.E., Ehninger,…

II. All Publications

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