Solid Tumors, Metastasis & Therapy Resistance

Hematopoietic Stem Cells and Leukemia

Stem Cells and Tumor Microenvironment

HI-STEM Group Leaders

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NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel
NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J.R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B.R., Caligiuri, M.A., Dirnhofer, S., Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A.*, Salih, H.R.*, & Lengerke, C.* (2019). Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature. doi: 10.1038/s41586-019-1410-1
*: joint senior authorship

Research Watch at Cancer Discovery on this article: PARP1 Inhibition Overcomes Immune Escape of Leukemic Stem Cells from NK cells

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