Research Group Stem Cells at the Interface of
hematopoiesis, Immunity and Cancer

Simon Haas
Junior Group Leader

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Highlight Publications

July 05, 2018

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)

Haas S, Trumpp A & Milsom MD (2018). "Causes and Consequences of Hematopoietic Stem Cell Heterogeneity." Cell Stem Cell, 22(5), 627-638. doi: 10.1016/j.stem.2018.04.003
June 13, 2017

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo (Cell Reports, 2017)

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. (2017) "Systemic Virus Infections Differentially Modulate Cell Cycle State…
March 20, 2017

Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)

Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM (2017). "Human haematopoietic stem cell lineage commitment is a continuous process."…
October 01, 2015

Inflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors (Cell Stem Cell, 2015)

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA (2015).…

All Publications

  • Haas, S., & Trumpp, A. (2018). An Intrinsic Interferon Program Protects Stem Cells from Viral Infection. Developmental Cell, 44(3), 279-280. doi: 10.1016/j.devcel.2018.01.013

  • Haas, S., Trumpp, A., & Milsom, M.D. (2018). Causes and Consequences of Hematopoietic Stem Cell Heterogeneity. Cell Stem Cell, 22(5), 627-638. doi: 10.1016/j.stem.2018.04.003

  • Gundry, M.C., Dever, D.P., Yudovich, D., Bauer, D.E., Haas, S., Wilkinson, A.C., & Singbrant, S. (2017). Technical considerations for the use of CRISPR/Cas9 in hematology research. Experimental hematology, 54, 4-11. doi: 10.1016/j.exphem.2017.07.006

  • Brocks, D., Schmidt, C.R., Daskalakis, M., Jang, H.S., Shah, N.M., Li, D., Li, J., Zhang, B., Hou, Y., & Laudato, S. (2017). DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nature genetics, 49(7), 1052. doi: 10.1038/ng1117-1661c

  • Hirche, C., Frenz, T., Haas, S.F., Döring, M., Borst, K., Tegtmeyer, P.-K., Brizic, I., Jordan, S., Keyser, K., & Chhatbar, C. (2017). Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo. Cell reports, 19(11), 2345-2356.     doi: 10.1016/j.celrep.2017.05.063 *Shared first author

  • Velten, L., Haas, S.F., Raffel, S., Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche, C., Lutz, C., Buss, E.C., & Nowak, D. (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nature cell biology, 19(4), 271. doi: 10.1038/ncb3493 * Shared first authorCover Story

  • Prendergast, Á.M., Kuck, A., van Essen, M., Haas, S., Blaszkiewicz, S., & Essers, M.A. (2017). IFNα-mediated remodeling of endothelial cells in the bone marrow niche. haematologica, 102(3), 445-453. doi: 10.3324/haematol.2016.151209

  • Uckelmann, H., Blaszkiewicz, S., Nicolae, C., Haas, S., Schnell, A., Wurzer, S., Wagener, R., Aszodi, A., & Essers, M.A.G. (2016). Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. Journal of Experimental Medicine, jem. 20151713. doi: 10.1084/jem.20151713

  • Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A., Prendergast, Á.M., Baumgärtner, D., Carnevalli, L.S., Atzberger, A., & Haas, S. (2016). Myc depletion induces a pluripotent dormant state mimicking diapause. Cell, 164(4), 668-680. doi: 10.1016/j.cell.2015.12.033

  • Paul, F., Arkin, Y., Giladi, A., Jaitin, D.A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., David, E., Cohen, N., Lauridsen, F.K.B., Haas, S., Schlitzer, A., Mildner, A., Ginhoux, F., Jung, S., Trumpp, A., Porse, B.T., Tanay, A., & Amit, I. (2016). Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell, 164(1-2), 325. doi: 10.1016/j.cell.2015.12.046

  • Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, A.M., Schnell, A., Hexel, K., Santarella-Mellwig, R., Blaszkiewicz, S., Kuck, A., Geiger, H., Milsom, M.D., Steinmetz, L.M., Schroeder, T., Trumpp, A., Krijgsveld, J., & Essers, M.A. (2015). Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell stem cell, 17(4), 422-434. doi: 10.1016/j.stem.2015.07.007

  • Becker, M., Schmezer, P., Breuer, R., Haas, S., Essers, M., Krammer, P., & Li-Weber, M. (2015). The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression. Cell death & disease, 5(1), e1000. doi: 10.1038/cddis.2013.528

  • Lipka, D.B., Wang, Q., Cabezas-Wallscheid, N., Klimmeck, D., Weichenhan, D., Herrmann, C., Lier, A., Brocks, D., von Paleske, L., & Renders, S. (2014). Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing. Cell Cycle, 13(22), 3476-3487. doi: 10.4161/15384101.2014.973334

  • Cabezas-Wallscheid, N., Klimmeck, D., Hansson, J., Lipka, D.B., Reyes, A., Wang, Q., Weichenhan, D., Lier, A., von Paleske, L., & Renders, S. (2014). Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell stem cell, 15(4), 507-522. doi: 10.1016/j.stem.2014.07.005

  • Ketzer, P., Haas, S.F., Engelhardt, S., Hartig, J.S., & Nettelbeck, D.M. (2012). Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses. Nucleic acids research, 40(21), e167-e167. doi: 10.1093/nar/gks734