Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for natural killer (NK) cells. This protective mechanism can be tricked with drugs. The exciting finding has been made by colleagues of the Trumpp team from HI-STEM and DKFZ together with the laboratories of Claudia Lengerke (Basel) and Helmut Salih (Tübingen) and was now published in Nature. Together with our collaborators, we now want to develop new therapeutic approaches based on these results.
Update: July 26,2019: The article has been featured in Research Watch at Cancer Discovery: PARP1 Inhibition Overcomes Immune Escape of Leukemic Stem Cells from NK cells
- DKFZ Press Release
- Read the Paper at Nature:
Anna M. Paczulla, Kathrin Rothfelder, Simon Raffel, Martina Konantz, Julia Steinbacher, Hui Wang, Claudia Tandler, Marcelle Mbarga, Thorsten Schaefer, Mattia Falcone, Eva Nievergall, Daniela Dörfel, Pauline Hanns, Jakob R. Passweg, Christoph Lutz, Juerg Schwaller, Robert Zeiser, Bruce R. Blazar, Michael A. Caligiuri, Stephan Dirnhofer, Pontus Lundberg, Lothar Kanz, Leticia Quintanilla-Martinez, Alexander Steinle, Andreas Trumpp, Helmut R. Salih, Claudia Lengerke: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion.
Nature 2019, DOI: 10.1038/s41586-019-1410-1
- Research Watch at Cancer Discovery: PARP1 Inhibition Overcomes Immune Escape of Leukemic Stem Cells from NK cells