May 05, 2022

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool (Cell Stem Cell, 2022)

Hernández-Malmierca P, Vonficht D, Schnell A, Uckelmann HJ, Bollhagen A, Mahmoud MAA, Landua SL, van der Salm E, Trautmann CL, Raffel S, Grünschläger F, Lutz R, Ghosh M, Renders S, Correia N, Donato E, Dixon KO, Hirche C, Andresen C, Robens C, Werner PS,…
May 03, 2022

CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells (Scientific Reports, 2022)

Sommerkamp P, Sommerkamp AC, Zeisberger P, Eiben PL, Narr A, Korkmaz A, Przybylla A, Sohn M, van der Hoeven F, Schönig K, Trumpp A. CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential…
April 28, 2022

Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs (Nature Cancer, 2022)

Hongu T, Pein M, Insua-Rodríguez J, Gutjahr E, Mattavelli G, Meier J, Decker K, Descot A, Bozza M, Harbottle R, Trumpp A, Sinn HP, Riedel A, Oskarsson T. Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a…
April 28, 2022

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis (Nature Cancer, 2022)

Alborzinia H*, Flórez AF*, Kreth S*, Brückner LM*, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Würth R, Stainczyk SA, Wecht EM, Kreth…
June 10, 2021

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells (Blood, 2021)

Sommerkamp, P., Romero-Mulero, M. C., Narr, A., Ladel, L., Hustin, L., Schonberger, K., Renders, S., Altamura, S., Zeisberger, P., Jacklein, K., Klimmeck, D., Rodriguez-Fraticelli, A., Camargo, F. D., Perie, L., Trumpp, A. & Cabezas-Wallscheid, N. (2021)…
March 01, 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics (Nature Communications, 2021)

Velten, L., Story, B.A., Hernandez-Malmierca, P., Raffel, S., Leonce, D.R., Milbank, J., Paulsen, M., Demir, A., Szu-Tu, C., Fromel, R., Lutz, C., Nowak, D., Jann, J.C., Pabst, C., Boch, T., Hofmann, W.K., Muller-Tidow, C., Trumpp, A., Haas, S., & Steinmetz,…
January 27, 2021

Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1 (Nature Communications, 2021)

Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P., Ladel, L., Redavid, A. R., Gibert, B., Lazare, S., Ducarouge, B., Schönberger, K., Narr, A., Tourbez, M., Dethmers-Ausema, B., Zwart, E., Hotz-Wagenblatt, A., Zhang, D.,…
October 15, 2020

Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin (Cancer Discovery, 2020)

Espinet, E.@, Gu, Z., Imbusch, C.D., Giese, N.A., Buscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., Insua-Rodriguez, J., Reitberger, M., Thiel, V., Kossi, S.O., Muckenhuber, A., Sarai, K., Lee, A.Y., Backx, E., Zarei, S., Gaida,…
June 18, 2020
Raffel et al., Blood 2020

Quantitative proteomics reveals specific metabolic features of Acute Myeloid Leukemia stem cells (Blood, 2020)

Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C., Tinelli, M., Bischel, O., Bullinger, L., Thiede, C., Florcken, A., Westermann, J., Ehninger, G., Ho, A.D., Muller-Tidow, C., Gu, Z., Herrmann, C., Krijgsveld, J., Trumpp,…
March 30, 2020

Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism (Cell Stem Cell, 2020)

Sommerkamp, P., Altamura, S., Renders, S., Narr, A., Ladel, L., Zeisberger, P., Eiben, P.L., Fawaz, M., Rieger, M.A., Cabezas-Wallscheid, N., & Trumpp, A. (2020). Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation…
March 20, 2020
Lung metastasis in a breast cancer patient: the arrows indicate fibroblasts (brown) that communicate with metastatic cancer cells. Cell nuclei are stained blue. © Oskarsson, DKFZ/HI-STEM

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs (Nature Communications, 2020)

Pein, M., Insua-Rodríguez, J., Hongu, T., Riedel, A., Meier, J., Wiedmann, L., Decker, K., Essers, M. A. G., Sinn, H. P., Spaich, S., Sutterlin, M., Schneeweiss, A., Trumpp, A. and Oskarsson, T. (2020). Metastasis-initiating cells induce and exploit a…
December 23, 2019

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization (Nature Cell Biology, 2020)

Baccin, C.*, Al-Sabah*, J., Velten, L.*@, Helbling, P. M., Grunschlager, F., Hernandez-Malmierca, P., Nombela-Arrieta, C., Steinmetz, L. M.@, Trumpp, A.@, & Haas, S.@ (2020). Combined single-cell and spatial transcriptomics reveal the molecular, cellular and…
November 05, 2019
Source: Saçma, M., Pospiech, J., Bogeska, R. et al. Haematopoietic stem cells in perisinusoidal niches are protected from ageing. Nat Cell Biol (2019) doi:10.1038/s41556-019-0418-y

Haematopoietic stem cells in perisinusoidal niches are protected from ageing (Nature, 2019)

Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., Soller, K., Marka, G., Vollmer, A., Karns, R., Cabezas-Wallscheid, N., Trumpp, A., Méndez-Ferrer, S., Milsom, M.D., Mulaw, M.A., Geiger, H., & Florian, M.C. (2019). Haematopoietic stem…
July 18, 2019
NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, 2019)

Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J.R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B.R., Caligiuri, M.A.,…
July 07, 2019

Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel (Cytometry A, 2019)

Eich, M., Trumpp, A., & Schmitt, S. (2019). OMIP-059: Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel. Cytometry A. doi:…
May 08, 2019
Meningioma heatmap

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma (Acta Neuropathologica, 2019)

Paramasivam, N.*, Hubschmann, D.*, Toprak, U.H., Ishaque, N., Neidert, M., Schrimpf, D., Stichel, D., Reuss, D., Sievers, P., Reinhardt, A., Wefers, A.K., Jones, D.T.W., Gu, Z., Werner, J., Uhrig, S., Wirsching, H.G., Schick, M., Bewerunge-Hudler, M., Beck,…

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma (Nature Communications, 2019)

Apr 09, 2019
Chordoma Research
Groschel, S.*, Hubschmann, D.*, Raimondi, F., Horak, P., Warsow, G., Frohlich, M., Klink,…

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma (Nature Communications, 2019)

Apr 02, 2019
Lopez, C.*, Kleinheinz, K.*, Aukema, S.M.*, Rohde, M.*, Bernhart, S.H.*, Hübschmann, D.*,…

The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells (Scientific Reports, 2019)

Feb 14, 2019
Sommerkamp, P., Renders, S., Ladel, L., Hotz-Wagenblatt, A., Schönberger, K., Zeisberger,…

Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis (EMBO Molecular Medicine, 2018)

Sep 06, 2018
Insua-Rodríguez J, Pein M, Hongu T, Meier J, Descot A, Lowy CM, De Braekeleer E, Sinn HP,…

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)

Jul 05, 2018
Haas, S., Trumpp, A., & Milsom, M.D. (2018). Causes and Consequences of Hematopoietic…

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (Nature, 2018)

Jan 17, 2018
Bahr, C.*, von Paleske, L.*, Uslu, V.V.*, Remeseiro, S., Takayama, N., Ng, S.W., Murison,…

BCAT1 restrictsαKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Nature, 2017)

Nov 10, 2017
Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L.,…

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo (Cell Reports, 2017)

Jun 13, 2017
Hirche, C., Frenz, T., Haas, S.F., Döring, M., Borst, K., Tegtmeyer, P.-K., Brizic, I.,…

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy (Cell, 2017)

May 18, 2017
Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L.,…

Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)

Mar 20, 2017
Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche,…

IFN alpha-mediated remodeling of endothelial cells in the bone marrow niche (Haematologica, 2017)

Oct 15, 2016
Prendergast, A.M., Kuck, A., van Essen, M., Haas, S., Blaszkiewicz, S., & Essers, M.A.G.…

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma (Nature Medicine, 2016)

Mar 22, 2016
Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel,…

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause (Cell, 2016)

Feb 16, 2016
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A.,…

Inflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors (Cell Stem Cell, 2015)

Oct 01, 2015
Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S.,…

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells (Nature, 2015)

Apr 23, 2015
Walter, D., Lier, A., Geiselhart, A., Thalheimer, F.B., Huntscha, S., Sobotta, M.C.,…