May 28, 2025
Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism
Cheytan T, Schneider M, Würth R, Schwerd-Kleine P, Gutjahr E, Thewes V, Michel LL, Weber R, Vorberg T, Lohr S, Nitschke K, Neßling M, Lichter P, Schneeweiss A, Richter K, Helm D, Sprick M, Trumpp A.
May 28, 2025
Clonal hematopoiesis landscape in frequent blood donors
Clonal hematopoiesis landscape in frequent blood donors Karpova D, Huerga Encabo H, Donato E, Calderazzo S, Scherer M, Llorian-Sopena M, Leppä AM, Würth R, Stelmach P, Papazoglou D, Ferrelli A, Ngo S, Kotova I, Harenkamp S, Zimmer K, Wolf D, Panten J, Reed…
January 13, 2025
Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling
Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling Würth R, Donato E, Michel LL, Saini M, Becker L, Cheytan T, Doncevic D, Messmer T, Gutjahr E, Weber R, Klein C, Alborzinia H, Yildiz U, Vogel V,…
January 13, 2025
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype Leppä AM, Grimes K, Jeong H, Huang FY, Andrades A, Waclawiczek A, Boch T, Jauch A, Renders S, Stelmach P, Müller-Tidow…
February 14, 2024
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis (Nature, 2024)
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S,…
January 10, 2024
Single-cell time series analysis reveals the dynamics of HSPC response to inflammation (Life Science Alliance, 2023)
Bouman BJ, Demerdash Y, Sood S, Grünschläger F, Pilz F, Itani AR, Kuck A, Marot-Lassauzaie V, Haas S, Haghverdi L, Essers MA. Single-cell time series analysis reveals the dynamics of HSPC response to inflammation. Life Sci Alliance. 2023 Dec 18;7(3):e202302309.…
September 15, 2023
Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
Saini M, Schmidleitner L, Moreno HD, Donato E, Falcone M, Bartsch JM, Klein C, Vogel V, Würth R, Pfarr N, Espinet E, Lehmann M, Königshoff M, Reitberger M, Haas S, Graf E, Schwarzmayr T, Strom TM, Spaich S, Sütterlin M, Schneeweiss A, Weichert W, Schotta G,…
September 15, 2023
Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax (Cancer Discovery, 2023)
Waclawiczek A, Leppä AM, Renders S, Stumpf K, Reyneri C, Betz B, Janssen M, Shahswar R, Donato E, Karpova D, Thiel V, Unglaub JM, Grabowski S, Gryzik S, Vierbaum L, Schlenk RF, Röllig C, Hundemer M, Pabst C, Heuser M, Raffel S, Müller-Tidow C, Sauer T, Trumpp…
September 15, 2023
LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma
Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN,…
July 26, 2022
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging (Cell Stem Cell, 2022)
Ruzhica Bogeska, Ana-Matea Mikecin, Paul Kaschutnig, Malak Fawaz, Marleen Büchler-Schäff, Duy Le, Miguel Ganuza, Angelika Vollmer, Stella V. Paffenholz, Noboru Asada, Esther Rodriguez-Correa, Felix Frauhammer, Florian Buettner, Melanie Ball, Julia Knoch, Sina…
May 05, 2022
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool (Cell Stem Cell, 2022)
Hernández-Malmierca P, Vonficht D, Schnell A, Uckelmann HJ, Bollhagen A, Mahmoud MAA, Landua SL, van der Salm E, Trautmann CL, Raffel S, Grünschläger F, Lutz R, Ghosh M, Renders S, Correia N, Donato E, Dixon KO, Hirche C, Andresen C, Robens C, Werner PS,…
May 03, 2022
CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells (Scientific Reports, 2022)
Sommerkamp P, Sommerkamp AC, Zeisberger P, Eiben PL, Narr A, Korkmaz A, Przybylla A, Sohn M, van der Hoeven F, Schönig K, Trumpp A. CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential…
April 28, 2022
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs (Nature Cancer, 2022)
Hongu T, Pein M, Insua-Rodríguez J, Gutjahr E, Mattavelli G, Meier J, Decker K, Descot A, Bozza M, Harbottle R, Trumpp A, Sinn HP, Riedel A, Oskarsson T. Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a…
April 28, 2022
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis (Nature Cancer, 2022)
Alborzinia H*, Flórez AF*, Kreth S*, Brückner LM*, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Würth R, Stainczyk SA, Wecht EM, Kreth…
June 10, 2021
Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells (Blood, 2021)
Sommerkamp, P., Romero-Mulero, M. C., Narr, A., Ladel, L., Hustin, L., Schonberger, K., Renders, S., Altamura, S., Zeisberger, P., Jacklein, K., Klimmeck, D., Rodriguez-Fraticelli, A., Camargo, F. D., Perie, L., Trumpp, A. & Cabezas-Wallscheid, N. (2021)…
March 01, 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics (Nature Communications, 2021)
Velten, L., Story, B.A., Hernandez-Malmierca, P., Raffel, S., Leonce, D.R., Milbank, J., Paulsen, M., Demir, A., Szu-Tu, C., Fromel, R., Lutz, C., Nowak, D., Jann, J.C., Pabst, C., Boch, T., Hofmann, W.K., Muller-Tidow, C., Trumpp, A., Haas, S., & Steinmetz,…
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1 (Nature Communications, 2021)
Jan 27, 2021
Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P.,…
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin (Cancer Discovery, 2020)
Oct 15, 2020
Espinet, E.@, Gu, Z., Imbusch, C.D., Giese, N.A., Buscher, M., Safavi, M., Weisenburger,…
Quantitative proteomics reveals specific metabolic features of Acute Myeloid Leukemia stem cells (Blood, 2020)
Jun 18, 2020
Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C.,…
Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism (Cell Stem Cell, 2020)
Mar 30, 2020
Sommerkamp, P., Altamura, S., Renders, S., Narr, A., Ladel, L., Zeisberger, P., Eiben,…
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs (Nature Communications, 2020)
Mar 20, 2020
Pein, M., Insua-Rodríguez, J., Hongu, T., Riedel, A., Meier, J., Wiedmann, L., Decker,…
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization (Nature Cell Biology, 2020)
Dec 23, 2019
Baccin, C.*, Al-Sabah*, J., Velten, L.*@, Helbling, P. M., Grunschlager, F.,…
Haematopoietic stem cells in perisinusoidal niches are protected from ageing (Nature, 2019)
Nov 05, 2019
Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., Soller, K.,…
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, 2019)
Jul 18, 2019
Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H.,…
Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel (Cytometry A, 2019)
Jul 07, 2019
Eich, M., Trumpp, A., & Schmitt, S. (2019). OMIP-059: Identification of Mouse…
Mutational patterns and regulatory networks in epigenetic subgroups of meningioma (Acta Neuropathologica, 2019)
May 08, 2019
Paramasivam, N.*, Hubschmann, D.*, Toprak, U.H., Ishaque, N., Neidert, M., Schrimpf, D.,…
Defective homologous recombination DNA repair as therapeutic target in advanced chordoma (Nature Communications, 2019)
Apr 09, 2019
Groschel, S.*, Hubschmann, D.*, Raimondi, F., Horak, P., Warsow, G., Frohlich, M., Klink,…
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma (Nature Communications, 2019)
Apr 02, 2019
Lopez, C.*, Kleinheinz, K.*, Aukema, S.M.*, Rohde, M.*, Bernhart, S.H.*, Hübschmann, D.*,…
The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells (Scientific Reports, 2019)
Feb 14, 2019
Sommerkamp, P., Renders, S., Ladel, L., Hotz-Wagenblatt, A., Schönberger, K., Zeisberger,…
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells (Cell Stem Cell, 2019)
Dec 20, 2018
Thier, M.C., Hommerding, O., Panten, J., Pinna, R., Garcia-Gonzalez, D., Berger, T.,…
Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis (EMBO Molecular Medicine, 2018)
Sep 06, 2018
Insua-Rodríguez J, Pein M, Hongu T, Meier J, Descot A, Lowy CM, De Braekeleer E, Sinn HP,…
Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)
Jul 05, 2018
Haas, S., Trumpp, A., & Milsom, M.D. (2018). Causes and Consequences of Hematopoietic…