June 10, 2021
Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells (Blood, 2021)
Sommerkamp, P., Romero-Mulero, M. C., Narr, A., Ladel, L., Hustin, L., Schonberger, K., Renders, S., Altamura, S., Zeisberger, P., Jacklein, K., Klimmeck, D., Rodriguez-Fraticelli, A., Camargo, F. D., Perie, L., Trumpp, A. & Cabezas-Wallscheid, N. (2021)…
March 01, 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics (Nature Communications, 2021)
Velten, L., Story, B.A., Hernandez-Malmierca, P., Raffel, S., Leonce, D.R., Milbank, J., Paulsen, M., Demir, A., Szu-Tu, C., Fromel, R., Lutz, C., Nowak, D., Jann, J.C., Pabst, C., Boch, T., Hofmann, W.K., Muller-Tidow, C., Trumpp, A., Haas, S., & Steinmetz,…
January 27, 2021
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1 (Nature Communications, 2021)
Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P., Ladel, L., Redavid, A. R., Gibert, B., Lazare, S., Ducarouge, B., Schönberger, K., Narr, A., Tourbez, M., Dethmers-Ausema, B., Zwart, E., Hotz-Wagenblatt, A., Zhang, D.,…
October 15, 2020
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin (Cancer Discovery, 2020)
Espinet, E.@, Gu, Z., Imbusch, C.D., Giese, N.A., Buscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., Insua-Rodriguez, J., Reitberger, M., Thiel, V., Kossi, S.O., Muckenhuber, A., Sarai, K., Lee, A.Y., Backx, E., Zarei, S., Gaida,…
June 18, 2020
Quantitative proteomics reveals specific metabolic features of Acute Myeloid Leukemia stem cells (Blood, 2020)
Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C., Tinelli, M., Bischel, O., Bullinger, L., Thiede, C., Florcken, A., Westermann, J., Ehninger, G., Ho, A.D., Muller-Tidow, C., Gu, Z., Herrmann, C., Krijgsveld, J., Trumpp,…
March 30, 2020
Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism (Cell Stem Cell, 2020)
Sommerkamp, P., Altamura, S., Renders, S., Narr, A., Ladel, L., Zeisberger, P., Eiben, P.L., Fawaz, M., Rieger, M.A., Cabezas-Wallscheid, N., & Trumpp, A. (2020). Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation…
March 20, 2020
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs (Nature Communications, 2020)
Pein, M., Insua-Rodríguez, J., Hongu, T., Riedel, A., Meier, J., Wiedmann, L., Decker, K., Essers, M. A. G., Sinn, H. P., Spaich, S., Sutterlin, M., Schneeweiss, A., Trumpp, A. and Oskarsson, T. (2020). Metastasis-initiating cells induce and exploit a…
December 23, 2019
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization (Nature Cell Biology, 2020)
Baccin, C.*, Al-Sabah*, J., Velten, L.*@, Helbling, P. M., Grunschlager, F., Hernandez-Malmierca, P., Nombela-Arrieta, C., Steinmetz, L. M.@, Trumpp, A.@, & Haas, S.@ (2020). Combined single-cell and spatial transcriptomics reveal the molecular, cellular and…
November 05, 2019
Haematopoietic stem cells in perisinusoidal niches are protected from ageing (Nature, 2019)
Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., Soller, K., Marka, G., Vollmer, A., Karns, R., Cabezas-Wallscheid, N., Trumpp, A., Méndez-Ferrer, S., Milsom, M.D., Mulaw, M.A., Geiger, H., & Florian, M.C. (2019). Haematopoietic stem…
July 18, 2019
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, 2019)
Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J.R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B.R., Caligiuri, M.A.,…
July 07, 2019
Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel (Cytometry A, 2019)
Eich, M., Trumpp, A., & Schmitt, S. (2019). OMIP-059: Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel. Cytometry A. doi:…
May 08, 2019
Mutational patterns and regulatory networks in epigenetic subgroups of meningioma (Acta Neuropathologica, 2019)
Paramasivam, N.*, Hubschmann, D.*, Toprak, U.H., Ishaque, N., Neidert, M., Schrimpf, D., Stichel, D., Reuss, D., Sievers, P., Reinhardt, A., Wefers, A.K., Jones, D.T.W., Gu, Z., Werner, J., Uhrig, S., Wirsching, H.G., Schick, M., Bewerunge-Hudler, M., Beck,…
April 09, 2019
Defective homologous recombination DNA repair as therapeutic target in advanced chordoma (Nature Communications, 2019)
Groschel, S.*, Hubschmann, D.*, Raimondi, F., Horak, P., Warsow, G., Frohlich, M., Klink, B., Gieldon, L., Hutter, B., Kleinheinz, K., Bonekamp, D., Marschal, O., Chudasama, P., Mika, J., Groth, M., Uhrig, S., Kramer, S., Heining, C., Heilig, C.E., Richter,…
April 02, 2019
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma (Nature Communications, 2019)
Lopez, C.*, Kleinheinz, K.*, Aukema, S.M.*, Rohde, M.*, Bernhart, S.H.*, Hübschmann, D.*, Wagener, R., Toprak, U.H., Raimondi, F., Kreuz, M., Waszak, S.M., Huang, Z., Sieverling, L., Paramasivam, N., Seufert, J., Sungalee, S., Russell, R.B., Bausinger, J.,…
February 14, 2019
The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells (Scientific Reports, 2019)
Sommerkamp, P., Renders, S., Ladel, L., Hotz-Wagenblatt, A., Schönberger, K., Zeisberger, P., Przybylla, A., Sohn, M., Zhou, Y., Klibanski, A., Cabezas-Wallscheid, N.@, & Trumpp, A.@ (2019). The long non-coding RNA Meg3 is dispensable for hematopoietic stem…
December 20, 2018
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells (Cell Stem Cell, 2019)
Thier, M.C., Hommerding, O., Panten, J., Pinna, R., Garcia-Gonzalez, D., Berger, T., Worsdorfer, P., Assenov, Y., Scognamiglio, R., Przybylla, A., Kaschutnig, P., Becker, L., Milsom, M.D., Jauch, A., Utikal, J., Herrmann, C., Monyer, H., Edenhofer, F., &…
Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis (EMBO Molecular Medicine, 2018)
Sep 06, 2018
Insua-Rodríguez J, Pein M, Hongu T, Meier J, Descot A, Lowy CM, De Braekeleer E, Sinn HP,…
Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)
Jul 05, 2018
Haas, S., Trumpp, A., & Milsom, M.D. (2018). Causes and Consequences of Hematopoietic…
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (Nature, 2018)
Jan 17, 2018
Bahr, C.*, von Paleske, L.*, Uslu, V.V.*, Remeseiro, S., Takayama, N., Ng, S.W., Murison,…
BCAT1 restrictsαKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Nature, 2017)
Nov 10, 2017
Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L.,…
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo (Cell Reports, 2017)
Jun 13, 2017
Hirche, C., Frenz, T., Haas, S.F., Döring, M., Borst, K., Tegtmeyer, P.-K., Brizic, I.,…
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy (Cell, 2017)
May 18, 2017
Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L.,…
Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)
Mar 20, 2017
Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche,…
IFN alpha-mediated remodeling of endothelial cells in the bone marrow niche (Haematologica, 2017)
Oct 15, 2016
Prendergast, A.M., Kuck, A., van Essen, M., Haas, S., Blaszkiewicz, S., & Essers, M.A.G.…
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma (Nature Medicine, 2016)
Mar 22, 2016
Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel,…
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause (Cell, 2016)
Feb 16, 2016
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A.,…
Inflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors (Cell Stem Cell, 2015)
Oct 01, 2015
Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S.,…
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells (Nature, 2015)
Apr 23, 2015
Walter, D., Lier, A., Geiselhart, A., Thalheimer, F.B., Huntscha, S., Sobotta, M.C.,…
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis (Cell Stem Cell, 2014)
Oct 04, 2014
Cabezas-Wallscheid, N., Klimmeck, D., Hansson, J., Lipka, D.B., Reyes, A., Wang, Q.,…
Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients (Oncotarget, 2014)
Sep 02, 2014
Baccelli, I., Stenzinger, A., Vogel, V., Pfitzner, B.M., Klein, C., Wallwiener, M.,…
Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit (Cell Stem Cell, 2014)
Jun 05, 2014
Medyouf, H., Mossner, M., Jann, J.C., Nolte, F., Raffel, S., Herrmann, C., Lier, A.,…
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay (Nature Biotechnology, 2013)
Apr 21, 2013
Baccelli, I., Schneeweiss, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V.,…