July 22, 2025
Federal Minister of Health visited DKFZ and HI-STEM
Federal Minister of Health Nina Warken visited DKFZ yesterday. After a warm welcome by Scientific Chair and CEO Prof. Michael Baumann, she also met with Dr. Rene Jackstadt (DKFZ, HI-STEM) to learn about his research on how tumors spread and metastasize in the…
July 22, 2025
Our Managing Director interviewed in Rhein Neckar Zeitung
Our Managing Director Andreas Trumpp was interviewed in Rhein Neckar Zeitung about our recent publication in Nature on neural innervation of tumors and their medical implications. Read the interview here:…
June 24, 2025
One of this year’s Else Kröner Memorial Fellowships to Mirco Friedrich
Else Kröner Fresenius Foundation awarded one of this year's Else Kröner Memorial Fellowships to HI-STEM Group Leader Mirco Friedrich. This fellowship provides two years of protected time away from clinical duties to clinician scientists to focus on their…
June 03, 2025
HI-STEM Group Leaders part of the new DFG funded collaborative research center for blood cancer
The German Research Foundation (DFG) will support the new Collaborative Research Center (SFB) 1709 “Cellular Plasticity in Malignant Myeloid Diseases – From Mechanism to Therapy” over the next four years. In around 20 working groups, scientists will…
June 03, 2025
Mirco Friedrich at the Forbes List "30 under 30 Europe"
Mirco Julian Friedrich, Junior Group Leader at HI-STEM, DKFZ and Heidelberg University Hospital (UKHD) has been included in the prestigious Forbes list “30 Under 30 Europe” in the Science & Healthcare category. The physician and cancer researcher, who has…
November 07, 2023
Congratulations to Michael Milsom!
With his publication "Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging" in the Journal Cell Stem Cell, Aug 2022, Michael Milsom received the GSCN 2023 Publication of the Year Award. Big…
July 26, 2022
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Inflammation and infection acutely suppress HSC function however, the long-term ramifications of such challenges are unclear. In this study HI-STEM researchers demonstrate that murine HSCs fail to recover functional potency up to 1 year post…
June 23, 2022
Gesucht wird MTA/BTA (m/w/d)
MTA/BTA (m/w/d) zur Unterstützung unserer Wissenschaftler bei der Durchführung von Projekten zur Identifizierung und Charakterisierung von Blut- und Krebsstammzellen gesucht! Qualifikationen Abgeschlossene Ausbildung als MTA oder BTA 3 Jahre Berufserfahrung…
May 05, 2022
How blood stem cells stay intact for a lifetime
Hematopoietic stem and progenitor cells (HSPCs) are responsible for the production of blood and immune cells. Throughout life, HSPCs acquire oncogenic aberrations that can cause hematological cancers. Although molecular programs maintaining stem cell…
May 03, 2022
CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells
HI-STEM researchers developed an inducible Pabpn1 knockout mouse model, which can be used to study Alternative Polyadenylation. Poly(A) binding protein nuclear 1 (PABPN1) is known for its role in poly(A) tail addition and regulation of poly(A) tail length. In…
April 28, 2022
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs.
Metastatic breast cancer cells abuse macrophages, a type of immune cell, to promote the settlement of cancer metastases in the lungs. The reprogrammed macrophages stimulate blood vessel cells to secrete a cocktail of metastasis-promoting proteins that are…
April 28, 2022
Tumors on withdrawal: Amino acid deficiency shrinks childhood tumors
Certain childhood tumors have an extreme need for amino acids. We together with scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ) and the University of Heidelberg, have now discovered the molecular…
April 28, 2022
ERC Advanced Grant for Andreas Trumpp
With its "Advanced Grants", the European Research Council ERC supports visionary projects in basic research. This year, the Council awarded Andreas Trumpp with the prestigious research grant. With the project called "SHATTER-AML", Andreas Trumpp wants to…
December 14, 2021
High recognition for Andreas Trumpp
At this year's annual meeting of the American Society of Hematology (ASH), held December 11-14 in Atlanta, Georgia, Andreas Trumpp delivered the prestigious Ham-Wasserman Lecture. In his lecture, the stem cell researcher reported on differences and…
September 01, 2021
Ferroptosis: Mechanism and Diseases
Hamed Alborzinia from Andreas Trumpp lab and his colleague Andres Florez Amaya of the Department of Molecular and Cellular Biology at Harvard University, published a book on ferroptosis entitled Ferroptosis: Mechanism and Diseases. Ferroptosis is a specific…
June 10, 2021
Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells
Previously, extensive research has focused on hematopoietic stem cells (HSCs) and distinct multipotent progenitor populations (MPP1-4) contained within the Lin- Sca-1+ c-Kit+ (LSK) compartment. In this new study, researchers around Pia Sommerkamp now…
March 22, 2021
MutaSeq: Single-cell analysis of leukemic stem cells - Cooperation with Velten and Steinmetz Lab published in Nature Communications
A new method called MutaSeq allows stem cells and cancer stem cells to be studied at the single cell level and the resulting cell clones to be traced directly. The method was developed by scientists from HI-STEM, the German Cancer Research Center (DKFZ), the…
January 27, 2021
How blood stem cells maintain their lifelong potential for self-renewal - New publication in Nature Communications
A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental…
November 10, 2020
HI-STEM Researchers discover new pancreatic cancer subtypes with different aggressiveness – Publication in Cancer Discovery
In a study led by HI-STEM researcher Elisa Espinet, HI-STEM researchers teamed up with an interdisciplinary group of clinicians, bioinformaticians and biomedical researchers to shed more light on the reasons for the heterogenous aggressiveness of different…
October 23, 2020
Pia Sommerkamp receives Wilma-Moser Prize
Pia Sommerkamp, who carried out her PhD at HI-STEM and the Division of Stem Cells and Cancer at the DKFZ until July 2019, has been awarded the Wilma-Moser Prize of Heidelberg University. The award annually honors the youngest female doctoral candidate…
July 28, 2020
8th GSCN Conference - goes virtual
The German Stem Cell Network (GSCN) aims to foster basic and applied stem cell research in Germany. HI-STEM is happy to forward the invitation by the GSCN to their 8th Annual Conference. The conference will be held from 23 - 25 September 2020 in a virtual…
March 31, 2020
Hidden messages in mRNA transcripts: Alternative polyadenylation (APA) is a novel control mechanism enabling hematopoietic stem cells (HSC) to adapt their activity to emergency situations– new publication in Cell Stem Cell
A team of researchers around Pia Sommerkamp, who carried out her PhD thesis in the HI-STEM lab and now continues as a Postdoc, now reports alternative polyadenylation (APA) as a new layer of gene regulation. In their study, the team, which involved colleagues…
How tumor cells create a metastatic niche – new work from the Oskarsson lab published in Nature Communications
Mar 24, 2020
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In order to colonize other organs and grow into metastases, tumor cells that detach from…
LeukoSystem: New BMBF-funded eMed Junior Consortium to investigate leukaemia causes and therapies
Mar 13, 2020
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The LeukoSyStem consortium, which is coordinated by HI-STEM group leader Simon Haas,…
German Cancer Prize Awarded to Andreas Trumpp
Feb 19, 2020
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On February 19, 2020, Andreas Trumpp, Managing Director of HI-STEM and Division Head at…
New paper out on Nature Cell Biology: 3D atlas of the bone marrow - in single cell resolution
Jan 07, 2020
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The lastest paper from the group of Simon Haas was published by Nature Cell Biology…
Andreas Trumpp recognized as Highly Cited Researcher 2019
Dec 10, 2019
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Andreas Trumpp has been recognized as a "Highly Cited Researcher" by the recently…
ÜBERLEBENSSTRATEGIEN: Science Communication Event with colleagues from the Stem Cell SFB (CRC873)
Nov 12, 2019
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On November 21, Andreas Trumpp will give a public presentation on "Stem Cells and Cancer"…
Mick elected into representative roles within both EHA and ASH.
Oct 11, 2019
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Mick Milsom has recently been elected as a chair of the Molecular Hematopiesis Workshop…
Making cancer stem cells visible to the immune system - New results may enable innovative treatment concept against leukemia (New publication in Nature)
Jul 18, 2019
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Leukemia stem cells protect themselves against the immune defense by suppressing a target…
A new tool to study hematopoiesis in detail: Optimized multicolor immunofluorescence panel differentiating major steps of blood development published in Cytometry (OMIP‐059)
Jul 11, 2019
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The mammalian blood system is one of the best-researched hierarchical stem cell systems.…
Her Honour Lieutenant Governor of Ontario Elizabeth Dowdeswell visits HI-STEM
Jun 05, 2019
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On June 4th, as part of her visit of the DKFZ, her Honour Lieutenant Governor of Ontario…
International Symposium FOR 2033: The Hematopoietic Niches; Munich, May 10th-11th, 2019
Apr 11, 2019
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Marieke Essers is co-organizing the International Symposium "The Hematopoietic Niches"…
Ten Years of HI-STEM – Founding Team Celebrates Successful Partnership on Cancer Stem Cell Research
Apr 02, 2019
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Ten years ago, HI-STEM, the Heidelberg Institute for Stem Cell Technology and…