Hematopoietic stem and progenitor cells (HSPCs) are responsible for the production of blood and immune cells. Throughout life, HSPCs acquire oncogenic aberrations that can cause hematological cancers. Although molecular programs maintaining stem cell…

HI-STEM researchers developed an inducible Pabpn1 knockout mouse model, which can be used to study Alternative Polyadenylation. Poly(A) binding protein nuclear 1 (PABPN1) is known for its role in poly(A) tail addition and regulation of poly(A) tail length. In…

Metastatic breast cancer cells abuse macrophages, a type of immune cell, to promote the settlement of cancer metastases in the lungs. The reprogrammed macrophages stimulate blood vessel cells to secrete a cocktail of metastasis-promoting proteins that are…

Certain childhood tumors have an extreme need for amino acids. We together with scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ) and the University of Heidelberg, have now discovered the molecular…

With its "Advanced Grants", the European Research Council ERC supports visionary projects in basic research. This year, the Council awarded Andreas Trumpp with the prestigious research grant. With the project called "SHATTER-AML", Andreas Trumpp wants to…

At this year's annual meeting of the American Society of Hematology (ASH), held December 11-14 in Atlanta, Georgia, Andreas Trumpp delivered the prestigious Ham-Wasserman Lecture. In his lecture, the stem cell researcher reported on differences and…

Hamed Alborzinia from Andreas Trumpp lab and his colleague Andres Florez Amaya of the Department of Molecular and Cellular Biology at Harvard University, published a book on ferroptosis entitled Ferroptosis: Mechanism and Diseases. Ferroptosis is a specific…

Previously, extensive research has focused on hematopoietic stem cells (HSCs) and distinct multipotent progenitor populations (MPP1-4) contained within the Lin- Sca-1+ c-Kit+ (LSK) compartment. In this new study, researchers around Pia Sommerkamp now…

A new method called MutaSeq allows stem cells and cancer stem cells to be studied at the single cell level and the resulting cell clones to be traced directly. The method was developed by scientists from HI-STEM, the German Cancer Research Center (DKFZ), the…

A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental…

In a study led by HI-STEM researcher Elisa Espinet, HI-STEM researchers teamed up with an interdisciplinary group of clinicians, bioinformaticians and biomedical researchers to shed more light on the reasons for the heterogenous aggressiveness of different…

Pia Sommerkamp, who carried out her PhD at HI-STEM and the Division of Stem Cells and Cancer at the DKFZ until July 2019, has been awarded the Wilma-Moser Prize of Heidelberg University. The award annually honors the youngest female doctoral candidate…

The German Stem Cell Network (GSCN) aims to foster basic and applied stem cell research in Germany. HI-STEM is happy to forward the invitation by the GSCN to their 8th Annual Conference. The conference will be held from 23 - 25 September 2020 in a virtual…

A team of researchers around Pia Sommerkamp, who carried out her PhD thesis in the HI-STEM lab and now continues as a Postdoc, now reports alternative polyadenylation (APA) as a new layer of gene regulation. In their study, the team, which involved colleagues…

In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'. Maren Pein and colleagues from the Oskarsson lab within HI-STEM and DKFZ…

The LeukoSyStem consortium, which is coordinated by HI-STEM group leader Simon Haas, investigates leukaemia stem cells in acute myeloid leukaemia (AML). The German Federal Ministry of Education and Research (BMBF) financially supports this collaboration with…

On February 19, 2020, Andreas Trumpp, Managing Director of HI-STEM and Division Head at the German Cancer Research Center (DKFZ), will receive the German Cancer Prize in the 'Experimental Research' category for his trailblazing work on identifying cancer stem…

The lastest paper from the group of Simon Haas was published by Nature Cell Biology shortly before Christmas last year. This is the result of a great team effort together with colleagues at the DKFZ and HI-STEM. The published methods are able to reveal the…

Andreas Trumpp has been recognized as a "Highly Cited Researcher" by the recently announced Web of Science list for 2019. The list recognizes "the world's most influential researchers of the past decade, demonstrated by the production of multiple highly-cited…

On November 21, Andreas Trumpp will give a public presentation on "Stem Cells and Cancer" as part of the event series Überlebensstrategien / Survival Strategies. The presentations will be in German. Survival Strategies is a joint project of the Life Science…

Mick Milsom has recently been elected as a chair of the Molecular Hematopiesis Workshop of the European Hematology Association (EHA) and also as a member of the Scientific Committee on Bone Marrow Failure of the American Society of Hematology (ASH). Both…

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for natural killer (NK) cells. This protective mechanism can be tricked with drugs. The exciting finding has been made by colleagues of the Trumpp team from…

The mammalian blood system is one of the best-researched hierarchical stem cell systems. It is also a main focus of the research in HI-STEM as it is a key for the understanding of the development of hematopoietic stem cells (HSCs) and the catastrophic…

On June 4th, as part of her visit of the DKFZ, her Honour Lieutenant Governor of Ontario Elizabeth Dowdeswel (@LGLizDowdeswell) visited the HI-STEM Lab. As part of her tour she showed great interest in our research on the role of stem cells in cancer.…