With its "Advanced Grants", the European Research Council ERC supports visionary projects in basic research. This year, the Council awarded Andreas Trumpp with the prestigious research grant. With the project called "SHATTER-AML", Andreas Trumpp wants to better understand which evolutionary processes occur in cancers characterized by structural genetic defects under the pressure of therapy. The results obtained from the example of CK-AML will also expand the understanding of other aggressive cancers that are also based on extensive chromosomal alterations. The goal of the scientists in Trumpp's laboratory is to develop more effective immunological and precision oncology therapies for these cancers, for which treatment options are often inadequate today.