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Inflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors (Cell Stem Cell, 2015)

In bone sections a strong increase in the number of polyploid megakaryocytes (red cells) was observed after treatment of mice with IFN

Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, A.M., Schnell, A., Hexel, K., Santarella-Mellwig, R., Blaszkiewicz, S., Kuck, A., Geiger, H., Milsom, M.D., Steinmetz, L.M., Schroeder, T., Trumpp, A., Krijgsveld, J., & Essers, M.A. (2015). Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell, 17(4), 422-434. doi: 10.1016/j.stem.2015.07.007

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Pubmed | Read at Publisher
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DKFZ Pressemitteilung (German)