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        Prof. Dr. Andreas Trumpp

        Prof. Dr. Andreas
        Trumpp

        Dr. Marieke Essers

        Dr. Marieke
        Essers

        Dr. Michael Milsom

        Dr. Michael
        Milsom

        Dr. Martin Sprick

        Dr. Martin
        Sprick

        Dr. Marc Thier

        Dr. Marc
        Thier

        Dr. Dr. Daniel Hübschmann

        Dr. Dr. Daniel
        Hübschmann

        Dr. Rene Jackstadt

        Dr. Rene
        Jackstadt

        Dr. Hamed Alborzinia

        Dr. Hamed
        Alborzinia

        Dr. Shubhankar Sood

        Dr. Shubhankar
        Sood

  • Research
      • Back
      • Normal & Malignant
        Stem Cells

        Normal & Malignant  Stem Cells
        Head:
        Prof. Dr. Andreas Trumpp

        Experimental
        Hematology

        Experimental Hematology
        Head:
        Dr. Mick Milsom

        Inflammatory Stress
        in Stem Cells

        Inflammatory Stress in Stem Cells
        Head:
        Dr. Marieke Essers

        Pattern Recognition &
        Digital Medicine


        Pattern Recognition & Digital Medicine
        Head:
        Dr. Dr. Daniel Hübschmann

        Stem Cells at the
        Interface of
        Hematopoiesis,
        Immunity & Cancer

        Stem Cells at the Interface of Hematopoiesis, Immunity & Cancer
        Head:
        Dr. Simon Haas

        Neural
        Reprogramming
        and Clinical
        Translation

        Neural Reprogramming and Clinical Translation
        Head:
        Dr. Marc Thier

        Stem Cells and
        Metastases

        Stem Cells and Metastases
        Head:
        Dr. Martin Sprick
        Prof. Dr. Andreas Trumpp

        Cancer Progression
        and Metastasis


        Cancer Progression  and Metastasis
        Head:
        Dr. Rene Jackstadt
      • Normal and Malignant Stem Cells
      • Experimental Hematology
      • Stem Cells and Metastases
      • Neural Reprogramming and Clinical Translation
      • Pattern Recognition
      • Stem Cells at the Interface of hematopoiesis, Immunity and Cancer
      • Stress Induced Activation of Hematopoietic Stem Cells
      • Cancer Progression and Metastasis
  • Outreach and Teaching
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      • Education
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      • Stem Cells and Cancer Conference
      • Scientific Environment
      • Heidelberg Leukemia Network
  • Publications
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      • News
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  • Translational Research
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      • Global Precision Medicine
  • 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis (Nature, 2024)

  • A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (Nature, 2018)

  • A new tool to study hematopoiesis in detail: Optimized multicolor immunofluorescence panel differentiating major steps of blood development published in Cytometry (OMIP‐059)

  • Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, 2019)

  • Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin (Cancer Discovery, 2020)

  • Awakening dormant haematopoietic stem cells (Nature Reviews Immunology, 2010)

  • BCAT1 restrictsαKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Nature, 2017)

  • c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation (Genes and Development, 2004)

  • c-Myc regulates mammalian body size by controlling cell number but not cell size (Nature, 2001)

  • Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)

  • Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling

  • Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax (Cancer Discovery, 2023)

  • Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization (Nature Cell Biology, 2020)

  • CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells

  • CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells (Scientific Reports, 2022)

  • CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma (Nature Medicine, 2016)

  • Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism (Cell Stem Cell, 2020)

  • Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells (Nature, 2015)

  • Haematopoietic stem cells in perisinusoidal niches are protected from ageing (Nature, 2019)

  • Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity (Cell Stem Cell, 2008)

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HI-STEM Movie

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News

December 12, 2025

Nature Magazin featured HI-STEM publication on cancer neuroscience in Outlook article

Role of neural cells in tumor progression is becoming ever more evident. HI-STEM scientists published a landmark study in Nature elucidating the role of neural innervation in promoting the tumor progression in pancreatic cancer and how this cross-talk works.…
Nov 14, 2025

Oral presentation by Sena Alptekin at the 13th GSCN Conference

Dr. Sena Alptekin, clinican scientist in the Milsom Group, gave an engaging talk during…
Jul 22, 2025

Federal Minister of Health visited DKFZ and HI-STEM

Federal Minister of Health Nina Warken visited DKFZ yesterday. After a warm welcome by…
Jul 22, 2025

Our Managing Director interviewed in Rhein Neckar Zeitung

Our Managing Director Andreas Trumpp was interviewed in Rhein Neckar Zeitung about our…
Jun 24, 2025

One of this year’s Else Kröner Memorial Fellowships to Mirco Friedrich

Else Kröner Fresenius Foundation awarded one of this year's Else Kröner Memorial…

HI-STEM is supported by:

  • German Cancer Reseach Center (DKFZ) Heidelberg
  • Dietmar Hopp Stiftung

Interesting Links

  • Heidelberg University Hospital
  • Mannheim University Hospital
  • National Center for Tumor Diseases Heidelberg

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HI-STEM gGmbH
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 6221 42-3901
office-trumpp@dkfz-heidelberg.de

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