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        Prof. Dr. Andreas Trumpp

        Prof. Dr. Andreas Trumpp

        Dr. Marieke Essers

        Dr. Marieke Essers

        Dr. Michael Milsom

        Dr. Michael Milsom

        Dr. Martin Sprick

        Dr. Martin Sprick

        Dr. Marc Thier

        Dr. Marc Thier

        Dr. Simon Haas

        Dr. Simon Haas

        Dr. Dr. Daniel Hübschmann

        Dr. Dr. Daniel
        Hübschmann

        Dr. Rene Jackstadt

        Dr. Rene Jackstadt

        Dr. Hamed Alborzinia

        Dr. Hamed Alborzinia

  • Research
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      • Normal & Malignant
        Stem Cells

        Normal & Malignant Stem Cells
        Head:
        Prof. Dr. Andreas Trumpp

        Experimental
        Hematology

        Experimental Hematology
        Head:
        Dr. Mick Milsom

        Inflammatory Stress
        in Stem Cells

        Inflammatory Stress in Stem Cells
        Head:
        Dr. Marieke Essers

        Pattern Recognition &
        Digital Medicine

        Pattern Recognition & Digital Medicine
        Head:
        Dr. Dr. Daniel Hübschmann

        Stem Cells at the
        Interface of
        Hematopoiesis,
        Immunity & Cancer

        Stem Cells at the Interface of Hematopoiesis, Immunity & Cancer
        Head:
        Dr. Simon Haas

        Neural
        Reprogramming
        and Clinical
        Translation

        Neural Reprogramming and Clinical Translation
        Head:
        Dr. Marc Thier

        Stem Cells and
        Metastases

        Stem Cells and Metastases
        Head:
        Dr. Martin Sprick
        Prof. Dr. Andreas Trumpp

        Cancer Progression
        and Metastasis

        Cancer Progression and Metastasis
        Head:
        Dr. Rene Jackstadt
      • Normal and Malignant Stem Cells
      • Experimental Hematology
      • Stem Cells and Metastases
      • Neural Reprogramming and Clinical Translation
      • Pattern Recognition
      • Stem Cells at the Interface of hematopoiesis, Immunity and Cancer
      • Stress Induced Activation of Hematopoietic Stem Cells
      • Cancer Progression and Metastasis
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  • Publications
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  • Translational Research
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      • GENAVINTA HEALTH

  • Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)

  • Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells (Nature, 2015)

  • Haematopoietic stem cells in perisinusoidal niches are protected from ageing (Nature, 2019)

  • Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells (Cell Stem Cell, 2019)

  • Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis (Cell Stem Cell, 2014)

  • Inflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors (Cell Stem Cell, 2015)

  • Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging (Cell Stem Cell, 2022)

  • New work online at bioRxiv

HI-STEM Movie

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News

June 24, 2025

One of this year’s Else Kröner Memorial Fellowships to Mirco Friedrich

Else Kröner Fresenius Foundation awarded one of this year's Else Kröner Memorial Fellowships to HI-STEM Group Leader Mirco Friedrich. This fellowship provides two years of protected time away from clinical duties to clinician scientists to focus on their…
Jun 03, 2025

HI-STEM Group Leaders part of the new DFG funded collaborative research center for blood cancer

The German Research Foundation (DFG) will support the new Collaborative Research Center…
Jun 03, 2025

Mirco Friedrich at the Forbes List "30 under 30 Europe"

Mirco Julian Friedrich, Junior Group Leader at HI-STEM, DKFZ and Heidelberg University…
Nov 07, 2023

Congratulations to Michael Milsom!

With his publication "Inflammatory exposure drives long-lived impairment of hematopoietic…
Jun 16, 2023

Oral presentation at the European Hematology Association annual meeting. Ian Ghezzi presented his PhD work on the role of cancer stem cell dormancy in disease propagation and therapy resistance of JAK2-mutated MPNs at the annual meeting of the European He

HI-STEM is supported by:

  • German Cancer Reseach Center (DKFZ) Heidelberg
  • Dietmar Hopp Stiftung

Interesting Links

  • Heidelberg University Hospital
  • Mannheim University Hospital
  • National Center for Tumor Diseases Heidelberg

Contact

HI-STEM gGmbH
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 6221 42-3901
office-trumpp@dkfz-heidelberg.de

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