Research Group Cancer Progression and Metastasis

Rene Jackstadt
Group Leader

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2021

  •  Jackstadt R, Norman JC. Stromal WNTer Keeps the Tumor Cold and Drives Metastasis. Dev Cell. 2021 Jan 11;56(1):3-4. doi: 10.1016/j.devcel.2020.12.011.
  •  Lannagan TR, Jackstadt R, Leedham SJ, Sansom OJ. Advances in colon cancer research: in vitro and animal models. Curr Opin Genet Dev. 2021 Jan 7;66:50-56. doi: 10.1016/j.gde.2020.12.003. Epub ahead of print.
  • Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E; CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nat Genet. 2021 Jan;53(1):16-26. doi: 10.1038/s41588-020-00753-3. Epub 2021 Jan 7

 2020

  • Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JDG, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ. MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discov. 2020 Dec 16:CD-20-0652. doi: 10.1158/2159-8290.CD-20-0652.

2019

  • Jackstadt, R., van Hooff, S.R., Leach, J.D., Cortes-Lavaud, X., Lohuis, J.O., Ridgway, R.A., Wouters, V.M., Roper, J., Kendall, T.J., Roxburgh, C.S., Horgan, P.G., Nixon, C., Nourse, C., Gunzer, M., Clark, W., Hedley, A., Yilmaz, O.H., Rashid, M., Bailey, P., Biankin, A.V., Campbell, A.D., Adams, D.J., Barry, S.T., Steele, C.W., Medema, J.P., & Sansom, O.J. (2019). Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis. Cancer Cell, 36(3), 319-336.e317. doi: 10.1016/j.ccell.2019.08.003
  • Gay, D.M., Ridgway, R.A., Müller, M., Hodder, M.C., Hedley, A., Clark, W., Leach, J.D., Jackstadt, R., Nixon, C., Huels, D.J., Campbell, A.D., Bird, T.G., & Sansom, O.J. (2019). Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nat Commun, 10(1), 723. doi: 10.1038/s41467-019-08586-3
  • Schmidt, S., Gay, D., Uthe, F.W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M.E., Bryson, S., Warrander, F.C., Erhard, F., Ade, C.P., Baluapuri, A., Walz, S., Jackstadt, R., Ford, C., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C., Maurus, K., Schmitz, W., Knight, J.R.P., Wolf, E., Strathdee, D., Schulze, A., Germer, C.T., Rosenwald, A., Sansom, O.J., Eilers, M., & Wiegering, A. (2019). A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nat Cell Biol, 21(11), 1413-1424. doi: 10.1038/s41556-019-0408-0

2018

  • Jaeckel, S., Kaller, M., Jackstadt, R., Götz, U., Müller, S., Boos, S., Horst, D., Jung, P., & Hermeking, H. (2018). Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells. Nat Commun, 9(1), 3573. doi: 10.1038/s41467-018-06001-x

2017

  • Jackstadt, R., & Sansom, O.J. (2017). The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair. Embo J, 36(1), 3-4. doi: 10.15252/embj.201695973

2016

  • Jackstadt, R., & Sansom, O.J. (2016). Mouse models of intestinal cancer. J Pathol, 238(2), 141-151. doi: 10.1002/path.4645

2015

  • Ormanns, S., Altendorf-Hofmann, A., Jackstadt, R., Horst, D., Assmann, G., Zhao, Y., Bruns, C., Kirchner, T., & Knösel, T. (2015). Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma. Br J Cancer, 113(10), 1460-1466. doi: 10.1038/bjc.2015.362
  • Jackstadt, R., & Hermeking, H. (2015). MicroRNAs as regulators and mediators of c-MYC function. Biochim Biophys Acta, 1849(5), 544-553. doi: 10.1016/j.bbagrm.2014.04.003

2014

  • Jackstadt, R., & Hermeking, H. (2014). AP4 is required for mitogen- and c-MYC-induced cell cycle progression. Oncotarget, 5(17), 7316-7327. doi: 10.18632/oncotarget.2348
  • Rokavec, M., Öner, M.G., Li, H., Jackstadt, R., Jiang, L., Lodygin, D., Kaller, M., Horst, D., Ziegler, P.K., Schwitalla, S., Slotta-Huspenina, J., Bader, F.G., Greten, F.R., & Hermeking, H. (2014). IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest, 124(4), 1853-1867. doi: 10.1172/jci73531
  • Cernat, L., Blaj, C., Jackstadt, R., Brandl, L., Engel, J., Hermeking, H., Jung, A., Kirchner, T., & Horst, D. (2014). Colorectal cancers mimic structural organization of normal colonic crypts. PLoS One, 9(8), e104284. doi: 10.1371/journal.pone.0104284
  • Shi, L., Jackstadt, R., Siemens, H., Li, H., Kirchner, T., & Hermeking, H. (2014). p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. Cancer Res, 74(2), 532-542. doi: 10.1158/0008-5472.Can-13-2203

2013

  • Hahn, S., Jackstadt, R., Siemens, H., Hünten, S., & Hermeking, H. (2013). SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. Embo J, 32(23), 3079-3095. doi: 10.1038/emboj.2013.236
  • Jackstadt, R., Jung, P., & Hermeking, H. (2013). AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation. Cell Death Dis, 4(8), e775. doi: 10.1038/cddis.2013.282
  • Jackstadt, R., Menssen, A., & Hermeking, H. (2013). Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA binding by next-generation sequencing. Methods Mol Biol, 1012, 145-185. doi: 10.1007/978-1-62703-429-6_11
  • Jackstadt, R., Röh, S., Neumann, J., Jung, P., Hoffmann, R., Horst, D., Berens, C., Bornkamm, G.W., Kirchner, T., Menssen, A., & Hermeking, H. (2013). AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer. J Exp Med, 210(7), 1331-1350. doi: 10.1084/jem.20120812
  • Siemens, H., Jackstadt, R., Kaller, M., & Hermeking, H. (2013). Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget, 4(9), 1399-1415. doi: 10.18632/oncotarget.1202
  • Siemens, H., Neumann, J., Jackstadt, R., Mansmann, U., Horst, D., Kirchner, T., & Hermeking, H. (2013). Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer. Clin Cancer Res, 19(3), 710-720. doi: 10.1158/1078-0432.Ccr-12-1703

2012

  • Drexler, S.K., Bonsignore, L., Masin, M., Tardivel, A., Jackstadt, R., Hermeking, H., Schneider, P., Gross, O., Tschopp, J., & Yazdi, A.S. (2012). Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A, 109(45), 18384-18389. doi: 10.1073/pnas.1209171109
  • Kriegl, L., Jung, A., Horst, D., Rizzani, A., Jackstadt, R., Hermeking, H., Gallmeier, E., Gerbes, A.L., Kirchner, T., Göke, B., & De Toni, E.N. (2012). Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer. PLoS One, 7(12), e51654. doi: 10.1371/journal.pone.0051654

2011

  • Siemens, H., Jackstadt, R., Hünten, S., Kaller, M., Menssen, A., Götz, U., & Hermeking, H. (2011). miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle, 10(24), 4256-4271. doi: 10.4161/cc.10.24.18552
  • Liffers, S.T., Maghnouj, A., Munding, J.B., Jackstadt, R., Herbrand, U., Schulenborg, T., Marcus, K., Klein-Scory, S., Schmiegel, W., Schwarte-Waldhoff, I., Meyer, H.E., Stühler, K., & Hahn, S.A. (2011). Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. BMC Cancer, 11, 137. doi: 10.1186/1471-2407-11-137

2010

  • Kriegl, L., Jung, A., Engel, J., Jackstadt, R., Gerbes, A.L., Gallmeier, E., Reiche, J.A., Hermeking, H., Rizzani, A., Bruns, C.J., Kolligs, F.T., Kirchner, T., Göke, B., & De Toni, E.N. (2010). Expression, cellular distribution, and prognostic relevance of TRAIL receptors in hepatocellular carcinoma. Clin Cancer Res, 16(22), 5529-5538. doi: 10.1158/1078-0432.Ccr-09-3403