Research Group Rene-Filip Jackstadt
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Research Group Cancer Progression and Metastasis

Rene Jackstadt
Group Leader

Publications

2022

  • Betge J, Jackstadt R. From organoids to bedside: Advances in modeling, decoding and targeting of colorectal cancer. Int J Cancer. 2022 Sep 19. doi: 10.1002/ijc.34297.

  • Vaquero-Siguero N, Schleussner N, Volk J, Mastel M, Meier J, Jackstadt R. Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection. Cancers (Basel). 2022 Aug 31;14(17):4260. doi: 10.3390/cancers14174260.

  • Weisshaar N, Wu J, Ming Y, Madi A, Hotz-Wagenblatt A, Ma S, Mieg A, Hering M, Zettl F, Mohr K, Schlimbach T, Ten Bosch N, Hertel F, Müller L, Byren H, Wang M, Borgers H, Munz M, Schmitt L, van der Hoeven F, Kloz U, Carretero R, Schleußner N, Jackstadt RF, Hofmann I, Cui G. Rgs16 promotes antitumor CD8+ T cell exhaustion. Sci Immunol. 2022 May 27;7(71):eabh1873. doi: 10.1126/sciimmunol.abh1873.

  • O'Connor MN, Kallenberg DM, Camilli C, Pilotti C, Dritsoula A, Jackstadt R, Bowers CE, Watson HA, Alatsatianos M, Ohme J, Dowsett L, George J, Blackburn JWD, Wang X, Singhal M, Augustin HG, Ager A, Sansom OJ, Moss SE, Greenwood J. LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med (N Y). 2021 Nov 12;2(11):1231-1252.e10. doi: 10.1016/j.medj.2021.10.002.

  • Corry SM, McCorry AM, Lannagan TR, Leonard NA, Fisher NC, Byrne RM, Tsantoulis P, Cortes-Lavaud X, Amirkhah R, Redmond KL, McCooey AJ, Malla SB, Rogan E, Sakhnevych S, Gillespie MA, White M, Richman SD, Jackstadt RF, Campbell AD, Maguire S; S:CORT and ACRCelerate consortia, McDade SS, Longley DB, Loughrey MB, Coleman HG, Kerr EM, Tejpar S, Maughan T, Leedham SJ, Small DM, Ryan AE, Sansom OJ, Lawler M, Dunne PD. Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut. 2022 Apr 27:gutjnl-2021-326183. doi: 10.1136/gutjnl-2021-326183.

2021

  • Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jørgensen C. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021 Jul 14

  • Krotenberg Garcia A, Fumagalli A, Le HQ, Jackstadt R, Lannagan TRM, Sansom OJ, van Rheenen J, Suijkerbuijk SJE. Active elimination of intestinal cells drives oncogenic growth in organoids. Cell Rep. 2021 Jul 6

  • Ramesh P, Lannagan TRM, Jackstadt R, Atencia Taboada L, Lansu N, Wirapati P, van Hooff SR, Dekker D, Pritchard J, Kirov AB, van Neerven SM, Tejpar S, Kops GJPL, Sansom OJ, Medema JP. BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer. Cell Death Differ. 2021 Jun 11.

  • Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium, van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ. Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nat Commun. 2021 Jun 8;12(1):3464

  • Nielsen SR, Strøbech JE, Horton ER, Jackstadt R, Laitala A, Bravo MC, Maltese G, Jensen ARD, Reuten R, Rafaeva M, Karim SA, Hwang CI, Arnes L, Tuveson DA, Sansom OJ, Morton JP, Erler JT. Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nat Commun. 2021 Jun 7;12(1):3414.

  • Jackstadt R, Norman JC. Stromal WNTer Keeps the Tumor Cold and Drives Metastasis. Dev Cell. 2021 Jan 11;56(1):3-4.

  • Lannagan TR, Jackstadt R, Leedham SJ, Sansom OJ. Advances in colon cancer research: in vitro and animal models. Curr Opin Genet Dev. 2021 Jan 7;66:50-56.

  • Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E; CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nat Genet. 2021 Jan;53(1):16-26.. 2020

  • Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JDG, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ. MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discov. 2020 Dec 16:CD-20-0652. doi: 10.1158/2159-8290.CD-20-0652.

2020

  • Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JDG, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ. MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discov. 2020 Dec 16:CD-20-0652.
  • Jackstadt R*, Hodder MC*., Sansom OJ.  Wnt and β-Catenin in Cancer: Genes and Therapy. Annu Rev Cancer Biol. 2020 4:1, 177-196 *equal first author contribution

2019

  • Jackstadt, R., van Hooff, S.R., Leach, J.D., Cortes-Lavaud, X., Lohuis, J.O., Ridgway, R.A., Wouters, V.M., Roper, J., Kendall, T.J., Roxburgh, C.S., Horgan, P.G., Nixon, C., Nourse, C., Gunzer, M., Clark, W., Hedley, A., Yilmaz, O.H., Rashid, M., Bailey, P., Biankin, A.V., Campbell, A.D., Adams, D.J., Barry, S.T., Steele, C.W., Medema, J.P., & Sansom, O.J. (2019). Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis. Cancer Cell, 36(3), 319-336.e317. doi: 10.1016/j.ccell.2019.08.003
  • Gay, D.M., Ridgway, R.A., Müller, M., Hodder, M.C., Hedley, A., Clark, W., Leach, J.D., Jackstadt, R., Nixon, C., Huels, D.J., Campbell, A.D., Bird, T.G., & Sansom, O.J. (2019). Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nat Commun, 10(1), 723. doi: 10.1038/s41467-019-08586-3
  • Schmidt, S., Gay, D., Uthe, F.W., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M.E., Bryson, S., Warrander, F.C., Erhard, F., Ade, C.P., Baluapuri, A., Walz, S., Jackstadt, R., Ford, C., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C., Maurus, K., Schmitz, W., Knight, J.R.P., Wolf, E., Strathdee, D., Schulze, A., Germer, C.T., Rosenwald, A., Sansom, O.J., Eilers, M., & Wiegering, A. (2019). A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nat Cell Biol, 21(11), 1413-1424. doi: 10.1038/s41556-019-0408-0

2018

  • Jaeckel, S., Kaller, M., Jackstadt, R., Götz, U., Müller, S., Boos, S., Horst, D., Jung, P., & Hermeking, H. (2018). Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells. Nat Commun, 9(1), 3573. doi: 10.1038/s41467-018-06001-x

2017

  • Jackstadt, R., & Sansom, O.J. (2017). The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair. Embo J, 36(1), 3-4. doi: 10.15252/embj.201695973

2016

  • Jackstadt, R., & Sansom, O.J. (2016). Mouse models of intestinal cancer. J Pathol, 238(2), 141-151. doi: 10.1002/path.4645

2015

  • Ormanns, S., Altendorf-Hofmann, A., Jackstadt, R., Horst, D., Assmann, G., Zhao, Y., Bruns, C., Kirchner, T., & Knösel, T. (2015). Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma. Br J Cancer, 113(10), 1460-1466. doi: 10.1038/bjc.2015.362
  • Jackstadt, R., & Hermeking, H. (2015). MicroRNAs as regulators and mediators of c-MYC function. Biochim Biophys Acta, 1849(5), 544-553. doi: 10.1016/j.bbagrm.2014.04.003

2014

  • Jackstadt, R., & Hermeking, H. (2014). AP4 is required for mitogen- and c-MYC-induced cell cycle progression. Oncotarget, 5(17), 7316-7327. doi: 10.18632/oncotarget.2348
  • Rokavec, M., Öner, M.G., Li, H., Jackstadt, R., Jiang, L., Lodygin, D., Kaller, M., Horst, D., Ziegler, P.K., Schwitalla, S., Slotta-Huspenina, J., Bader, F.G., Greten, F.R., & Hermeking, H. (2014). IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest, 124(4), 1853-1867. doi: 10.1172/jci73531
  • Cernat, L., Blaj, C., Jackstadt, R., Brandl, L., Engel, J., Hermeking, H., Jung, A., Kirchner, T., & Horst, D. (2014). Colorectal cancers mimic structural organization of normal colonic crypts. PLoS One, 9(8), e104284. doi: 10.1371/journal.pone.0104284
  • Shi, L., Jackstadt, R., Siemens, H., Li, H., Kirchner, T., & Hermeking, H. (2014). p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. Cancer Res, 74(2), 532-542. doi: 10.1158/0008-5472.Can-13-2203

2013

  • Hahn, S., Jackstadt, R., Siemens, H., Hünten, S., & Hermeking, H. (2013). SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. Embo J, 32(23), 3079-3095. doi: 10.1038/emboj.2013.236
  • Jackstadt, R., Jung, P., & Hermeking, H. (2013). AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation. Cell Death Dis, 4(8), e775. doi: 10.1038/cddis.2013.282
  • Jackstadt, R., Menssen, A., & Hermeking, H. (2013). Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA binding by next-generation sequencing. Methods Mol Biol, 1012, 145-185. doi: 10.1007/978-1-62703-429-6_11
  • Jackstadt, R., Röh, S., Neumann, J., Jung, P., Hoffmann, R., Horst, D., Berens, C., Bornkamm, G.W., Kirchner, T., Menssen, A., & Hermeking, H. (2013). AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer. J Exp Med, 210(7), 1331-1350. doi: 10.1084/jem.20120812
  • Siemens, H., Jackstadt, R., Kaller, M., & Hermeking, H. (2013). Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget, 4(9), 1399-1415. doi: 10.18632/oncotarget.1202
  • Siemens, H., Neumann, J., Jackstadt, R., Mansmann, U., Horst, D., Kirchner, T., & Hermeking, H. (2013). Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer. Clin Cancer Res, 19(3), 710-720. doi: 10.1158/1078-0432.Ccr-12-1703

2012

  • Drexler, S.K., Bonsignore, L., Masin, M., Tardivel, A., Jackstadt, R., Hermeking, H., Schneider, P., Gross, O., Tschopp, J., & Yazdi, A.S. (2012). Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A, 109(45), 18384-18389. doi: 10.1073/pnas.1209171109
  • Kriegl, L., Jung, A., Horst, D., Rizzani, A., Jackstadt, R., Hermeking, H., Gallmeier, E., Gerbes, A.L., Kirchner, T., Göke, B., & De Toni, E.N. (2012). Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer. PLoS One, 7(12), e51654. doi: 10.1371/journal.pone.0051654

2011

  • Siemens, H., Jackstadt, R., Hünten, S., Kaller, M., Menssen, A., Götz, U., & Hermeking, H. (2011). miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle, 10(24), 4256-4271. doi: 10.4161/cc.10.24.18552
  • Liffers, S.T., Maghnouj, A., Munding, J.B., Jackstadt, R., Herbrand, U., Schulenborg, T., Marcus, K., Klein-Scory, S., Schmiegel, W., Schwarte-Waldhoff, I., Meyer, H.E., Stühler, K., & Hahn, S.A. (2011). Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. BMC Cancer, 11, 137. doi: 10.1186/1471-2407-11-137

2010

  • Kriegl, L., Jung, A., Engel, J., Jackstadt, R., Gerbes, A.L., Gallmeier, E., Reiche, J.A., Hermeking, H., Rizzani, A., Bruns, C.J., Kolligs, F.T., Kirchner, T., Göke, B., & De Toni, E.N. (2010). Expression, cellular distribution, and prognostic relevance of TRAIL receptors in hepatocellular carcinoma. Clin Cancer Res, 16(22), 5529-5538. doi: 10.1158/1078-0432.Ccr-09-3403