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Research Group Neural Reprogramming and Clinical Translation

Marc Thier
Group Leader

Highlight Publications

Other Selected Publications

Marc Christian Thier, Oliver Hommerding, Jasper Panten, Roberta Pinna, Diego García-González, Thomas Berger, Philipp Wörsdörfer, Yassen Assenov, Roberta Scognamiglio, Adriana Przybylla, Paul Kaschutnig, Lisa Becker, Michael D. Milsom, Anna Jauch, Jochen Utikal, Carl Herrmann, Hannah Monyer, Frank Edenhofer & Andreas Trumpp. Identification of Embryonic Neural Plate Border Stem Cells and their generation by direct reprogramming from human blood. CELL Stem Cell. 2019 Jan 3;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015


Paul Kaschutnig, Irem Bayindir-Buchhalter, Marc Thier, Wiebke Nadler, Sabrina Hanke, Stella Paffenholz, Milena Block, Ruzhica Bogeska, David Hills, Andreas Trumpp, Christoph Rösli, Alexander Medvinsky, Michael Milsom. Functional and molecular segregation of in vitro specified hematopoietic stem and progenitor cells using a HOXB4 knock-in reporter. Exp. Hematol. VOLUME 44, ISSUE 9, SUPPLEMENT , S84, SEPTEMBER 01, 2016.


Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A. Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell. 2016 Feb 11;164(4):668-80.


Münst B*, Thier MC*, Winnemöller D*, Helfen M, Thummer RP, Edenhofer F. Nanog induces suppression of senescence via down-regulation of p27KIP1 expression. *Authors contributed equally. J Cell Sci. 2016 Mar 1;129(5):912-20.


Bung R*, Wörsdörfer P*, Thier MC*, Vogt K, Gebhardt M, Edenhofer F. Partial dedifferentiation of murine radial glia type neural stem cells by Brn2 and c-Myc yields early neuroepithelial progenitors. *Authors contributed equallyJ Mol Biol. 2016 Apr 10;428(7):1476-83.


Meyer S, Wörsdörfer P, Günther K, Thier M, Edenhofer F. Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells. J Vis Exp. 2015 Jul 29;(101):e52831.


Kim BM, Thier MC, Oh S, Sherwood R, Kanellopoulou C, Edenhofer F, Choi MY. MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells. PLoS One. 2012;7(6):e39239.


Thier M, Münst B, Mielke S, Edenhofer F. Cellular reprogramming employing recombinant sox2 protein. Stem Cells Int. 2012;2012:549846.


Haupt, S., J. Grützner, M.-C. Thier, F. Edenhofer, B. H. Rath, I. Laufenberg., M. Forgber, J. Eberhardt & O. Brüstle, Automated selection and harvesting of pluripotent stem cell colonies. Biotechnol Appl Biochem. 2012 Mar-Apr;59(2):77-87.


Thier*, Philipp Wörsdörfer*, Yenal Bernhard Lakes*, Raphaela Gorris, Stefan Herms, Thoralf Opitz, Dominic Seiferling, Tamara Quandel, Per Hoffmann, Markus Nöthen, Oliver Brüstle, and Frank Edenhofer. Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells. CELL Stem Cell. 2012 Apr 6;10(4):473-9.


Thier, B. Münst, F Edenhofer. Exploring refined conditions for reprogramming cells by recombinant Oct4 protein. International Journal of Developmental Biology. Int J Dev Biol. 2010;54(11-12):1713-21.



Wörsdörfer P*, Thier M*, Kadari A*, Edenhofer F. Roadmap to cellular reprogramming - manipulating transcriptional networks with DNA, RNA, proteins and small molecules. *Authors contributed equally. Curr Mol Med. 2013 Jun;13(5):868-78 

Bosnali*, B. Münst*, M. Thier*, F. Edenhofer. Deciphering the stem cell machinery as a basis for understanding the molecular mechanism underlying reprogramming. *Authors contributed equally. Cell Mol Life Sci. 2009 Nov;66(21):3403-20.