In the study, which was led by HI-STEM postdoc Marc Thier, we have succeeded for the first time to directly reprogram human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely in the culture dish and can represent an important basis for the development of regenerative therapies.

Within the study, the team has succeed for the first time to reprogram mature human cells in such a way that a defined type of induced neural stem cells is produced that can multiply almost indefinitely. The work was a cooperation with stem cell researcher Frank Edenhofer from the University of Innsbruck and neuroscientist Hannah Monyer from DKFZ and appeared in Cell Stem Cell.

Further reading

Marc Christian Thier, Oliver Hommerding, Jasper Panten, Roberta Pinna, Diego García-González, Thomas Berger, Philipp Wörsdörfer, Yassen Assenov, Roberta Scognamiglio, Adriana Przybylla, Paul Kaschutnig, Lisa Becker, Michael D. Milsom, Anna Jauch, Jochen Utikal, Carl Herrmann, Hannah Monyer, Frank Edenhofer und Andreas Trumpp. Cell Stem Cell (2018), DOI: 10.1016/j.stem.2018.11.015

 

Andreas Trumpp together with Minister of Science and Education Theresia Bauer

The State Research Prize for Applied Research (Landesforschungspreis) of Baden-Württemberg 2018 is awarded to Andreas Trumpp. The Minister for Science, Research and Art Theresia Bauer presented the award, which includes a prize money of 100.000 Euro, during a ceremonial act on December 10th, 2018 in Stuttgart. HI-STEM director Trumpp is honored for his remarkable contributions to the research field of stem cells and cancer. For instance he and his team discovered that stem cells of the blood are protected from environmental damage and chemotherapy through the principle of cellular dormancy. This significant body of work has led the way to numerous clinical research projects with the aim to develop better therapies for cancer patients.

The chairman of the DKFZ Michael Baumann said on the occasion of the award: "Andreas Trumpp is worldwide one of the outstanding researchers in the field of cancer stem cells to which he has contributed to significantly." In her remarks, Minister Theresia Bauer emphasized the importance of leading researchers such as Andreas Trumpp for the attractiveness of Baden-Württemberg.

Further Information and Media Coverage (in German)

 Image Gallery of the Award Ceremony

Pictures: Jan Potente / MWK

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  1. Marieke Essers receives the Prize of the Berlin-Brandenburg Academy of Sciences and Humanities
  2. International Behr-Symposium on Stem Cells and Cancer
  3. HI STEM researchers show link between stress signaling and chemotherapy resistant metastasis in breast cancer
  4. Andreas Trumpp elected as Board Member of the European Association for Cancer Research (EACR)
  5. HI-STEM Teams Win Gold and Silver at the DKFZ’s Sommerfest Cup!
  6. New Review in Cell Stem Cell: Causes and Consequences of Hematopoietic Stem Cell Heterogeneity
  7. Double sucess for HI-STEM researchers Simon Haas and Simon Raffel
  8. Ten years of successful research on cancer stem cells at HI-STEM – Third funding period announced!
  9. HI-STEM participates in UniStem Day 2018
  10. Marieke Essers receives the Chica and Heinz Schaller Research Award
  11. Regulating Stem Cell Function from Long Distances: HI-STEM Team and Colleagues Describe New Layers of Myc Regulation in Nature
  12. Nature Paper on BCAT1 overexpression in leukemia featured in Cancer Discovery

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