Milsom - copy
Research Group Experimental Hematology

Mick Milsom
Senior Group Leader

News Milsom Group

  • Ruzhica Bogeska to present at Basel Stem Cell Network

    Congratulations to Ruzhica Bogeska, whose abstract has been selected for oral presentation at the Basel Stem Cell Meeting, “Stem cell dynamics throughout life: from development to the adult”. The meeting will take place in August in Basel.

  • Sina Stäble awarded the DKFZ/Weizmann Institute Fellowship

    Big congratulations to Sina Stäble, who was awarded a DKFZ/Weizmann Institute Cancer TRAX PhD-to Postdoc Fellowship. The award will fund an additional two year’s of research for Sina, as she continues to work on a combined project between the Division of Experimental Hematology and the Division of Epigenomics and Cancer Risk Factors, co-supervised by Mick and Daniel Lipka. The Fellowship will also fund a six month research visit to the laboratory of Amos Tanay, at the Weizmann Institute in Israel.

  • Jeyan Jeyarajan awarded the DKFZ/Helmholtz Graduate Fellowship

    Congratulations to Jeyan Jeyarajan, who has been awarded a fellowship from the DKFZ Helmholtz International Graduate School to fund the duration of her research studies within the group.

  • Project grant from the DFG

    The Division of Experimental Hematology, has just been awarded a four year project grant as part of the third renewal of the SFB873 Collaborative Research Centre on Stem Cell Biology. The funding mechanism from the DFG, supports a Heidelberg-based consortium focussed on studying the maintenance and differentiation of stem cells in development and disease. The project grant is a direct collaboration between the Division of Experimental Hematology and the Stress-Induced Activation of Hematopoietic Stem Cells Research Group, headed by Dr. Marieke Essers, which will start in July 2018.

  • Marleen Büchler awarded the DKFZ/Helmholtz Graduate Fellowship

    Congratulations to Marleen Büchler, who has been awarded a fellowship from the DKFZ Helmholtz International Graduate School to fund the duration of her research studies within the group.

  • New Review in Cell Stem Cell: Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

    Classically, stem and progenitor populations have been considered discrete homogeneous populations. However, recent technological advances have revealed significant hematopoietic stem cell (HSC) heterogeneity, with evidence for early HSC lineage segregation and the presence of lineage-biased HSCs and lineage-restricted progenitors within the HSC compartment. These and other findings challenge many aspects of the classical view of HSC biology.

    In our recent review in Cell Stem Cell, we analyse the most recent findings regarding the causes and consequences of HSC heterogeneity, discuss their far-reaching implications, and suggest that so-called continuum-based models may help consolidate apparently divergent experimental observations in this field.

    Read more:

     

  • Renewal of project funding from the Fritz Thyssen Stiftung

    The Division has recently successfully renewed its project funding from the Fritz Thyssen Stiftung to study the aetiology of bone marrow failure in Fanconi anemia. The additional one year of funding will mean that the foundation will have supported this research project for a duration of three years

  • Dr. Mick Milsom joins Editorial Board of ASH Journal "Blood"

    As of January 2018, Dr. Mick Milsom has joined the Editorial Board of Blood, the official journal of the American Society for Hematology (ASH).

  • Dr. Mick Milsom joins Editorial Board of EHA Journal "HemaSphere"

    Dr. Mick Milsom has joined the Scientific Editorial Board of the journal HemaSphere, the newly launched official journal of the European Hematology Association.

  • Project funding from the Helmholtz Association

    The Division of Experimental Hematology has been awarded project funding as part of a Helmholtz Association-wide call for funding on future topics relating to health. The consortium is focussed on the topic of Ageing and Metabolic Programming (AMPro) and the funding period will run for three years.

  • Project grant from the MPN Research Foundation

    The Division of Experimental Hematology has been awarded a one year project grant from the MPN Research Foundation to study the effects of interferon-alpha on MPN stem cells.

  • Three year DFG funding for aging-associated epigenetics research

    The Division of Experimental Hematology formed part of a multi-center consortium that successfully applied for a three year funding program from the DFG, to study aging-associated epigenetic as a therapeutic target in acute myeloid leukemia. The Division’s role in the Forschergruppe will be to investigate epigenetic remodelling and clonal selection in a murine model of accelerated hematopoietic stem cell aging, and will be carried out in collaboration with Dr. Daniel Lipka from the Divison of Epigenomics and Cancer Risk Factors.

  • Project Grant for collaborative research with Ben-Gurion University, Israel

    The Division of Experimental Hematology has been awarded a DKFZ-MOST Cooperation in Cancer Research Project Grant in order to fund collaborative research between the Division and the group of Roi Gazit at Ben-Gurion University in Israel.

  • Project grant from the Deutsche Krebshilfe

    In collaboration with the group of Daniel Lipka, in the Division of Epigenomics and Cancer Risk Factors, the Division has been awarded a Project Grant from the Deutsche Krebshilfe to study epigenetic plasticity in pre-leukemic hematopoiesis. March 2017.

  • Natasha Anstee awarded a DKFZ Postdoctoral Fellowship

    Congratulations to Dr. Natasha Anstee, who has been awarded a DKFZ Postdoctoral Fellowship, to fund her work within the group.

  • HI-STEM group leader receives David B. Frohnmayer Award.

    Dr. Michael Milsom was recently awarded the 2016 Fanconi Anemia Research Fund’s David B. Frohnmeyer Early Investigator Award.  The award is given to independent investigators of high accomplishment within 10 years of starting their own group. Dr. Milsom is the second recipient of this award, which was established in 2015 in memory of David Frohnmayer, former Attorney General of the US state of Oregon, President of the University of Oregon, and founder of the Fanconi Anemia Research Foundation.

    Dr. Milsom received this award in light of his pioneering work on the roles of DNA damage and Fanconi anemia signaling pathway function in governing the attrition of hematopoietic stem cells. Dr. Ray Monnat, Chair of the Fanconi Anemia Research Fund Scientific Advisory Board commented that “This is a topic of high, and growing, interest both within the Fanconi anemia community and experimental hematology in general.”

     

     

  • Dr. Mick Milsom elected on to the Board of Directors for the ISEH

    Dr. Mick Milsom has been elected on to the Board of Directors for the International Society for Experimental Hematology (ISEH), for a three year term.

  • HI-STEM scientist’s work recognized with DKFZ award

    Dr. Dagmar Walter and Dr. Amelie Lier were awarded the 2015 Waltraud Lewenz prize for work carried out in the HI-STEM group, Experimental Hematology, led by Dr. Michael Milsom. The prize is awarded annually to young scientists who have published work judged to have furthered the understanding of cancer risk factors, cancer prevention or early detection of cancer. Drs. Walter and Lier were given this award based on the manuscript that they published in the prestigious journal Nature in April 2015, “Exit from dormancy provokes DNA damage-induced attrition in haematopoietic stem cells.”  The manuscript describes how environmental stress factors such as infection, inflammation and injury can lead to hematopoietic stem cell loss and the acquisition of potential cancer-causing mutations within the stem cell compartment.  As well as providing a new mechanism and model to study how cancer develops from the accumulation of DNA mutations within stem cells, this work also sheds new light on how stress-induced stem cell attrition is a likely driving force behind the normal ageing process.

    References

    Walter D., Lier A, Geiselhart A., Thalheimer F.B., Huntscha S., Sobotta M.C., Moehrle B., Brocks D., Bayindir I., Kaschutnig P., Müdder K., Klein C., Jauch A., Schroeder T., Geiger H., Dick T.P., Holland-Letz T., Schmezer P., Lane S.W., Rieger M.A., Essers M.A.G., Williams D.A.W., Trumpp A.and Milsom M.D.(2015). Exit from dormancy provokes DNA damage-induced attrition in haematopoietic stem cells. Nature,520(7548): pp549-552).