Prince William and his wife, Duchess Catherine, visited the HI-STEM laboratory on July 20, 2017
As part of their official visit to Germany, Prince William and his wife, Duchess Catherine, visited the HI-STEM laboratory on July 20, 2017. Here, HI-STEM group leader Mick Milsom had the chance to introduce them into latest results of his group. The visit was part of a tour through the DKFZ, which was the first stop of the royal visit to Heidelberg.
During the visit, Milsom explained to the royal couple how a misdirected gene in blood stem cells can cause a particularly aggressive form of blood cancer. “The Duchess and the Duke were very interested in how our work relates to the development of new therapies for cancer patients and asked a number of great questions about this.” says Milsom.
“The visit was a great honor for the whole HI-STEM team and will be remembered for a long time by all of us.” says Andreas Trumpp, the managing director of HI-STEM.
 
 
  • Hematopoiesis
  • Kate Microscope
  • William Microscope
  • Explaining Microscope
  • Mick describes the normal hematopoietic system to the Duke and Duchess, and explains how this is perturbed in the setting of leukemia.
  • The Duchess of Cambridge looks at colonies formed by leukemic cells under the microscope.
  • The Duke of Cambridge looks at colonies formed by leukemic cells under the microscope.
  • Mick fields a question from the Duke of Cambridge.

Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)

Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche, C., Lutz, C., Buss, E.C., Nowak, D., Boch, T., Hofmann, W.K., Ho, A.D., Huber, W., Trumpp, A.@, Essers, M.A.@, & Steinmetz, L.M.@ (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nature Cell Biology, 19(4), 271-281. doi: 10.1038/ncb3493 Cover Story *Shared first author @Shared corresponding author 


Scientists at HI-STEM have uncovered a yet unknown mechanism for therapy resistance in pancreatic cancer based on overexpression of the enzyme CYP3A5. The paper was published in Nature Medicine.

Read more:

·         DKFZ Press Release: Pancreatic Cancer: Enzyme renders tumors resistant

·         Citation: Noll, E.M., Eisen, C., Stenzinger, A., Espinet, E., Muckenhuber, A., Klein, C., Vogel, V., Klaus, B., Nadler, W., Rosli, C., Lutz, C., Kulke, M., Engelhardt, J., Zickgraf, F.M., Espinosa, O., Schlesner, M., Jiang, X.Q., Kopp-Schneider, A., Neuhaus, P., Bahra, M., Sinn, B.V., Eils, R., Giese, N.A., Hackert, T., Strobel, O., Werner, J., Buchler, M.W., Weichert, W., Trumpp, A., & Sprick, M.R. (2016). CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nature Medicine, 22(3), 278-287. doi: 10.1038/nm.4038

 

 

Dr. Michael Milsom was recently awarded the 2016 Fanconi Anemia Research Fund’s David B. Frohnmeyer Early Investigator Award.  The award is given to independent investigators of high accomplishment within 10 years of starting their own group. Dr. Milsom is the second recipient of this award, which was established in 2015 in memory of David Frohnmayer, former Attorney General of the US state of Oregon, President of the University of Oregon, and founder of the Fanconi Anemia Research Foundation.

Dr. Milsom received this award in light of his pioneering work on the roles of DNA damage and Fanconi anemia signaling pathway function in governing the attrition of hematopoietic stem cells. Dr. Ray Monnat, Chair of the Fanconi Anemia Research Fund Scientific Advisory Board commented that “This is a topic of high, and growing, interest both within the Fanconi anemia community and experimental hematology in general.”

 

 

February 15, 2016

In a process called diapause, many animal species delay the development of their embryos in order to ensure that their offspring is born at a possibly favorable time. Scientists from DKFZ and HI-STEM have now shown that this process is regulated by the MYC oncogene. If MYC is turned off in mice, embryonic stem cells and early embryos enter a reversible biochemical state of dormancy. However, this does not affect their ability to differentiate into any cell type of the body. When MYC is reactivated, the dormant embryos are able to develop into healthy animals. These findings have been published in the latest issue of “Cell” and were featured as the cover story.

Read more:

·         DKFZ Press Release

·         Citation: Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A., Prendergast, A.M., Baumgartner, D., Carnevalli, L.S., Atzberger, A., Haas, S., von Paleske, L., Boroviak, T., Worsdorfer, P., Essers, M.A., Kloz, U., Eisenman, R.N., Edenhofer, F., Bertone, P., Huber, W., van der Hoeven, F., Smith, A., & Trumpp, A. (2016). Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell, 164(4), 668-680. doi: 10.1016/j.cell.2015.12.033

Cell

  1. HI-STEM scientist’s work recognized with DKFZ award
  2. Andreas Trumpp featured in GSCN Video Clip on Stem Cell Research

Subcategories

News Milsom