Classically, stem and progenitor populations have been considered discrete homogeneous populations. However, recent technological advances have revealed significant hematopoietic stem cell (HSC) heterogeneity, with evidence for early HSC lineage segregation and the presence of lineage-biased HSCs and lineage-restricted progenitors within the HSC compartment. These and other findings challenge many aspects of the classical view of HSC biology.

In our recent review in Cell Stem Cell, we analyse the most recent findings regarding the causes and consequences of HSC heterogeneity, discuss their far-reaching implications, and suggest that so-called continuum-based models may help consolidate apparently divergent experimental observations in this field.

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Two awards at once, both carrying high monetary prizes, go to two HI-STEM members: Simon Raffel will receive the 2017 Walter Schulz Prize for his discovery how misregulated breakdown of amino acids in leukemia stem cells promotes blood cancer. To find out more about this work, read our news feature.

Simon Haas will share the 2018 Otto Schmeil Prize with his colleague Lars Velten from EMBL. The two stem cell researchers have jointly demonstrated that the development of blood cells in the bone marrow follows very different paths from what scientists have assumed up to now.

 

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Since its installation in 2008, HI-STEM can look back at ten years of successful research. On March 28, 2018, the Dietmar-Hopp Foundation and the DKFZ have announced that the funding for HI-STEM will be prolonged until 20203. Additionally two new projects on circulating tumor cells and therapy resistance in pancreatic cancer.

All members of HI-STEM are grateful for the continuous generous support by the Dietmar Hopp Foundation and the DKFZ and are looking forward to five more years of exciting research!

Further Information:

On February 5, 2018, the Chica and Heinz Schaller Research Award were presented to HI-STEM Group Leader Marieke Essers during the official award ceremony at Heidelberg University. She received the award for her pioneering work on hematopoietic stem cells and their activation during stress conditions. The award is endowed with 100,000 euros. Prof. Petra Boukamp, a researcher at the Leibniz Research Institute for Environmental Medicine and former division head at the DKFZ, emphasized during her laudation, how Marieke, as a successful scientist and team leader made important contributions to the elucidation of stem cell functions in hematopoiesis and the role of inflammatory processes on them.

Marieke, who has been a group leader at HI-STEM since 2009, especially thanked the Dietmar-Hopp-Foundation for the generous support of the research carried out at HI-STEM, which is run as a public-private partnership between the German Cancer Research Center (DKFZ) and the foundation.

The second award was presented to Dr. Theodore Alexandrov from the European Molecular Biology Laboratory (EMBL) for his pioneering work in metabolome research.

Further Information:

·         Press Release of German Cancer Resarch Center

·         Website of the Chica and Heinz Schaller Foundation

·         Research Group Marieke Essers: Stress-induced Activation of Hematopoietic Stem Cells

  • CHS Preis 01
    The awardees Theodore Alexandrov and Marieke Essers together with the representative of the Chica and Heinz Schaller Foundation and the laudators. From left to right: Rohini Kuner, Karoly Nikolich, Theodore Alexandrov, Marieke Essers, Hans-Georg Kräusslich, Petra Boukamp, Rüdiger Hell (Photo:Philipp Rothe)
  • CHS Preis 03
    The management board of the DKFZ, Prof. Michael Baumann (left) and Prof. Josef Puchta (right) also congratulated the awardees. (Photo:Philipp Rothe)

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