The LeukoSyStem consortium, which is coordinated by HI-STEM group leader Simon Haas, investigates leukaemia stem cells in acute myeloid leukaemia (AML). The German Federal Ministry of Education and Research (BMBF) financially supports this collaboration with a total sum of €2.45 M for five years as part of its eMED program on systems medicine. LeukoSystem is a collaboration between junior researchers, namely Dr. Simon Raffel (Heidelberg University Hospital), Lars Velten (CRG Barcelona), Laleh Haghverdi (EMBL Heidelberg) and Simon Haas (HI-STEM gGmbH and German Cancer Research Center (DKFZ)).

The aim of their project is to investigate the cells that are the origin of acute myeloid leukaemia (AML) and thus "get to the root of the problem". The scientists intend to use isolated single cells from patient samples to investigate characteristic markers, mutations, functional data, and metabolic pathways, to gain a better understanding of leukaemia stem cells and their environment in the bone marrow. The collected data will be evaluated comprehensively with the help of computer algorithms specially developed for the purpose.


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Andreas Trumpp © Jutta Jung/DKFZ

On February 19, 2020, Andreas Trumpp, Managing Director of HI-STEM and Division Head at the German Cancer Research Center (DKFZ), will receive the German Cancer Prize in the 'Experimental Research' category for his trailblazing work on identifying cancer stem cells in different types of cancer. The German Cancer Prize, sponsored by the German Cancer Society and the German Cancer Foundation, is one of the most prestigious awards in German oncology. The award ceremony for the researchers will be held at the 34th German Cancer Congress in Berlin.

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Highly Cited 2019

Andreas Trumpp has been recognized as a "Highly Cited Researcher" by the recently announced Web of Science list for 2019. The list recognizes "the world's most influential researchers of the past decade, demonstrated by the production of multiple highly-cited papers that rank in the top 1% by citations for field and year in Web of Science."

Find more on our recent publications at Publications or at https://publons.com/researcher/3129471/andreas-trumpp/

Of course this great success would not have been possible without fellow co-workers, collaborators and funders!

Three dimensional segmentation of a bone marrow region. Different niche cells (green and red dots) and blood vessels (grey) are highlighted. | © DKFZ, EMBL and University Hospital Zurich

The lastest paper from the group of Simon Haas was published by Nature Cell Biology shortly before Christmas last year. This is the result of a great team effort together with colleagues at the DKFZ and HI-STEM.

The published methods are able to reveal the three-dimensional organization of the bone marrow at the single cell level. Using this approach the teams have identified previously unknown cell types that create specific local environments required for blood generation from stem cells. The study reveals an unexpected complexity of the bone marrow and its microdomains at an unprecedented resolution and provides a novel scientific basis to study blood diseases such as leukemias.

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  • Original Paper: Baccin, C.*, Al-Sabah*, J., Velten, L.*@, Helbling, P. M., Grunschlager, F., Hernandez-Malmierca, P., Nombela-Arrieta, C., Steinmetz, L. M.@, Trumpp, A.@, & Haas, S.@ (2019). Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology. doi: 10.1038/s41556-019-0439-6 *: Shared first authors, @ Joint Supervising authors
  • News and Views Article: Lucas, D., Salomonis, N., & Grimes, H. L. (2019). Unraveling bone marrow architecture. Nat Cell Biol. doi: 10.1038/s41556-019-0447-6
  • DKFZ Press Release
  • EMBL Press Release
Plakt ÜBERLEBENSSTRATEGIEN

On November 21, Andreas Trumpp will give a public presentation on "Stem Cells and Cancer" as part of the event series Überlebensstrategien / Survival Strategies. The presentations will be in German.

Survival Strategies is a joint project of the Life Science Collaborative Research Centres of the University of Heidelberg and the Rhein-Neckar-Zeitung (RNZ). The editors of the Rhein-Neckar Zeitung accompany each event with their personal questions on the research topics presented, the scientists involved and the methods. This format of moderation is intended to form a lively bridge to the audience, which is included in the dialogue. In an informal setting at the Karlstorbahnhof and with musical accompaniment by members of the Collegium Musicum, the Collaborative Research Centres will present their questions and long-term goals.

Further Information on the University Website

On the 21st of November the following members of our CRC 873 will present:

  • Jan Lohmann: Einführung
  • Andreas Trumpp: Stammzellen und Krebs
  • Carmen Ruiz de Almodóvar: Blutgefäße: Heimat von Stammzellen
  • Henrik Kaessmann: Stammzellen und Evolution

Start will be at 19:30

Location : Karlstorbahnhof, Club K, Am Karlstor 1, 69117 Heidelberg

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