Research Group Stem Cells at the Interface of
hematopoiesis, Immunity and Cancer

Simon Haas
Junior Group Leader

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Highlight Publications

March 01, 2021

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics (Nature Communications, 2021)

Velten, L., Story, B.A., Hernandez-Malmierca, P., Raffel, S., Leonce, D.R., Milbank, J., Paulsen, M., Demir, A., Szu-Tu, C., Fromel, R., Lutz, C., Nowak, D., Jann, J.C., Pabst, C., Boch, T., Hofmann, W.K., Muller-Tidow, C., Trumpp, A., Haas, S., & Steinmetz,…
July 05, 2018

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity (Cell Stem Cell, 2018)

Haas, S., Trumpp, A., & Milsom, M.D. (2018). Causes and Consequences of Hematopoietic Stem Cell Heterogeneity. Cell Stem Cell, 22(5), 627-638. doi: 10.1016/j.stem.2018.04.003
June 13, 2017

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo (Cell Reports, 2017)

Hirche, C., Frenz, T., Haas, S.F., Döring, M., Borst, K., Tegtmeyer, P.-K., Brizic, I., Jordan, S., Keyser, K., & Chhatbar, C. (2017). Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells…
March 20, 2017

Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)

Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche, C., Lutz, C., Buss, E.C., Nowak, D., Boch, T., Hofmann, W.K., Ho, A.D., Huber, W., Trumpp, A.@, Essers, M.A.@, & Steinmetz, L.M.@ (2017). Human haematopoietic stem cell…
October 01, 2015

Inflammation-induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors (Cell Stem Cell, 2015)

Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, A.M., Schnell, A., Hexel, K., Santarella-Mellwig, R., Blaszkiewicz, S., Kuck, A., Geiger, H., Milsom, M.D., Steinmetz, L.M., Schroeder, T., Trumpp, A.,…

All Publications

  • Haas, S., & Trumpp, A. (2018). An Intrinsic Interferon Program Protects Stem Cells from Viral Infection. Developmental Cell, 44(3), 279-280. doi: 10.1016/j.devcel.2018.01.013

  • Haas, S., Trumpp, A., & Milsom, M.D. (2018). Causes and Consequences of Hematopoietic Stem Cell Heterogeneity. Cell Stem Cell, 22(5), 627-638. doi: 10.1016/j.stem.2018.04.003

  • Gundry, M.C., Dever, D.P., Yudovich, D., Bauer, D.E., Haas, S., Wilkinson, A.C., & Singbrant, S. (2017). Technical considerations for the use of CRISPR/Cas9 in hematology research. Experimental Hematology, 54, 4-11. doi: 10.1016/j.exphem.2017.07.006

  • Brocks, D., Schmidt, C.R., Daskalakis, M., Jang, H.S., Shah, N.M., Li, D., Li, J., Zhang, B., Hou, Y., & Laudato, S. (2017). DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nature Genetics, 49(7), 1052. doi: 10.1038/ng.3889

  • Hirche, C.*, Frenz, T.*, Haas, S.F.*, Döring, M., Borst, K., Tegtmeyer, P.-K., Brizic, I., Jordan, S., Keyser, K., & Chhatbar, C. (2017). Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo. Cell Reports, 19(11), 2345-2356.     doi: 10.1016/j.celrep.2017.05.063 *Shared first author

  • Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche, C., Lutz, C., Buss, E.C., Nowak, D., Boch, T., Hofmann, W.K., Ho, A.D., Huber, W., Trumpp, A.@, Essers, M.A.@, & Steinmetz, L.M.@ (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nature Cell Biology, 19(4), 271-281. doi: 10.1038/ncb3493 Cover Story *Shared first author @Shared corresponding author 

  • Prendergast, Á.M., Kuck, A., van Essen, M., Haas, S., Blaszkiewicz, S., & Essers, M.A. (2017). IFNα-mediated remodeling of endothelial cells in the bone marrow niche. Haematologica, 102(3), 445-453. doi: 10.3324/haematol.2016.151209

  • Uckelmann, H., Blaszkiewicz, S., Nicolae, C., Haas, S., Schnell, A., Wurzer, S., Wagener, R., Aszodi, A., & Essers, M.A.G. (2016). Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. Journal of Experimental Medicine, jem. 20151713. doi: 10.1084/jem.20151713

  • Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A., Prendergast, Á.M., Baumgärtner, D., Carnevalli, L.S., Atzberger, A., & Haas, S. (2016). Myc depletion induces a pluripotent dormant state mimicking diapause. Cell, 164(4), 668-680. doi: 10.1016/j.cell.2015.12.033

  • Paul, F., Arkin, Y., Giladi, A., Jaitin, D.A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., David, E., Cohen, N., Lauridsen, F.K.B., Haas, S., Schlitzer, A., Mildner, A., Ginhoux, F., Jung, S., Trumpp, A., Porse, B.T., Tanay, A., & Amit, I. (2016). Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. Cell, 164(1-2), 325. doi: 10.1016/j.cell.2015.12.046

  • Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, A.M., Schnell, A., Hexel, K., Santarella-Mellwig, R., Blaszkiewicz, S., Kuck, A., Geiger, H., Milsom, M.D., Steinmetz, L.M., Schroeder, T., Trumpp, A., Krijgsveld, J., & Essers, M.A. (2015). Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell, 17(4), 422-434. doi: 10.1016/j.stem.2015.07.007

  • Becker, M., Schmezer, P., Breuer, R., Haas, S., Essers, M., Krammer, P., & Li-Weber, M. (2015). The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression. Cell Death & Disease, 5(1), e1000. doi: 10.1038/cddis.2013.528

  • Lipka, D.B., Wang, Q., Cabezas-Wallscheid, N., Klimmeck, D., Weichenhan, D., Herrmann, C., Lier, A., Brocks, D., von Paleske, L., & Renders, S. (2014). Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing. Cell Cycle, 13(22), 3476-3487. doi: 10.4161/15384101.2014.973334

  • Cabezas-Wallscheid, N., Klimmeck, D., Hansson, J., Lipka, D.B., Reyes, A., Wang, Q., Weichenhan, D., Lier, A., von Paleske, L., & Renders, S. (2014). Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Cell Stem Cell, 15(4), 507-522. doi: 10.1016/j.stem.2014.07.005

  • Ketzer, P., Haas, S.F., Engelhardt, S., Hartig, J.S., & Nettelbeck, D.M. (2012). Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses. Nucleic Acids Research, 40(21), e167-e167. doi: 10.1093/nar/gks734