Solid Tumors and Metastasis

Solid Tumors, Metastasis & Therapy Resistance

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Solid Tumors and Metastasis
Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia

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Hematopoietic Stem Cells and Leukemia
Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment

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Stem Cells and Tumor Microenvironment
The HI-STEM Team

The HI-STEM Team

HI-STEM features an interdisciplinary research team.
The HI-STEM Team
HI-STEM Group Leaders

HI-STEM Group Leaders

HI-STEM Group Leaders
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Hernández-Malmierca P, Vonficht D, Schnell A, Uckelmann HJ, Bollhagen A, Mahmoud MAA, Landua SL, van der Salm E, Trautmann CL, Raffel S, Grünschläger F, Lutz R, Ghosh M, Renders S, Correia N, Donato E, Dixon KO, Hirche C, Andresen C, Robens C, Werner PS, Boch T, Eisel D, Osen W, Pilz F, Przybylla A, Klein C, Buchholz F, Milsom MD, Essers MAG, Eichmüller SB, Hofmann WK, Nowak D, Hübschmann D, Hundemer M, Thiede C, Bullinger L, Müller-Tidow C, Armstrong SA, Trumpp A, Kuchroo VK, Haas S. Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.

Cell Stem Cell. 2022 May 5;29(5):760-775.e10. doi:10.1016/j.stem.2022.04.007 PMID: 35523139.

Sommerkamp P, Sommerkamp AC, Zeisberger P, Eiben PL, Narr A, Korkmaz A, Przybylla A, Sohn M, van der Hoeven F, Schönig K, Trumpp A. CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells.

Scientific Reports 2022 May 3;12(1):7181. doi: 10.1038/s41598-022-11203-x PMID: 35504940; PMCID: PMC9065150.

Hongu T, Pein M, Insua-Rodríguez J, Gutjahr E, Mattavelli G, Meier J, Decker K, Descot A, Bozza M, Harbottle R, Trumpp A, Sinn HP, Riedel A, Oskarsson T. Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs. Nat Cancer. 2022 Apr 25. doi:10.1038/s43018-022-00353-6 Epub ahead of print. PMID: 35469015.

Alborzinia H*, Flórez AF*, Kreth S*, Brückner LM*, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Würth R, Stainczyk SA, Wecht EM, Kreth J, Büttner M, Ishaque N, Schlesner M, Nicke B, Stresemann C, Llamazares-Prada M, Reiling JH, Fischer M, Amit I, Selbach M, Herrmann C, Wölfl S, Henrich KO, Höfer T, Trumpp A, Westermann F.  MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis.

Nature Cancer. 2022 Apr;3(4):471-485. doi: 10.1038/s43018-022-00355-4. Epub 2022 Apr 28. PMID: 35484422; PMCID: PMC9050595.