Solid Tumors and Metastasis

Solid Tumors, Metastasis & Therapy Resistance

Solid Tumors and Metastasis
Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia
Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment
HI-STEM Group Leaders

HI-STEM Group Leaders

HI-STEM Group Leaders
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Meningioma heatmap

Paramasivam, N.*, Hubschmann, D.*, Toprak, U.H., Ishaque, N., Neidert, M., Schrimpf, D., Stichel, D., Reuss, D., Sievers, P., Reinhardt, A., Wefers, A.K., Jones, D.T.W., Gu, Z., Werner, J., Uhrig, S., Wirsching, H.G., Schick, M., Bewerunge-Hudler, M., Beck, K., Brehmer, S., Urbschat, S., Seiz-Rosenhagen, M., Hanggi, D., Herold-Mende, C., Ketter, R., Eils, R., Ram, Z., Pfister, S.M., Wick, W., Weller, M., Grossmann, R., von Deimling, A., Schlesner, M., & Sahm, F. (2019). Mutational patterns and regulatory networks in epigenetic subgroups of meningioma. Acta Neuropathol, 138(2), 295-308. doi: 10.1007/s00401-019-02008-w
*: Shared first authorship

Chordoma Research

Groschel, S.*, Hubschmann, D.*, Raimondi, F., Horak, P., Warsow, G., Frohlich, M., Klink, B., Gieldon, L., Hutter, B., Kleinheinz, K., Bonekamp, D., Marschal, O., Chudasama, P., Mika, J., Groth, M., Uhrig, S., Kramer, S., Heining, C., Heilig, C.E., Richter, D., Reisinger, E., Pfutze, K., Eils, R., Wolf, S., von Kalle, C., Brandts, C., Scholl, C., Weichert, W., Richter, S., Bauer, S., Penzel, R., Schrock, E., Stenzinger, A., Schlenk, R.F., Brors, B., Russell, R.B., Glimm, H.*, Schlesner, M.*, & Frohling, S.* (2019). Defective homologous recombination DNA repair as therapeutic target in advanced chordoma. Nat Commun, 10(1), 1635. doi: 10.1038/s41467-019-09633-9
*: equal contribution

NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J.R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B.R., Caligiuri, M.A., Dirnhofer, S., Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A.*, Salih, H.R.*, & Lengerke, C.* (2019). Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature. doi: 10.1038/s41586-019-1410-1
*: joint senior authorship

Research Watch at Cancer Discovery on this article: PARP1 Inhibition Overcomes Immune Escape of Leukemic Stem Cells from NK cells