Solid Tumors and Metastasis

Solid Tumors, Metastasis & Therapy Resistance

Solid Tumors and Metastasis
Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia
Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment
HI-STEM Group Leaders

HI-STEM Group Leaders

HI-STEM Group Leaders
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Raffel et al., Blood 2020

Raffel, S., Klimmeck, D., Falcone, M., Demir, A., Pouya, A., Zeisberger, P., Lutz, C., Tinelli, M., Bischel, O., Bullinger, L., Thiede, C., Florcken, A., Westermann, J., Ehninger, G., Ho, A.D., Muller-Tidow, C., Gu, Z., Herrmann, C., Krijgsveld, J., Trumpp, A.@, & Hansson, J.@ (2020). Quantitative proteomics reveals specific metabolic features of Acute Myeloid Leukemia stem cells. BLOOD. doi: 10.1182/blood.2019003654

Lung metastasis in a breast cancer patient: the arrows indicate fibroblasts (brown) that communicate with metastatic cancer cells. Cell nuclei are stained blue. © Oskarsson, DKFZ/HI-STEM

Pein, M., Insua-Rodríguez, J., Hongu, T., Riedel, A., Meier, J., Wiedmann, L., Decker, K., Essers, M. A. G., Sinn, H. P., Spaich, S., Sutterlin, M., Schneeweiss, A., Trumpp, A. and Oskarsson, T. (2020). Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs. Nature Communications, 11(1), 1494. DOI: 10.1038/s41467-020-15188-x

Feature in at Ärzteblatt.de: https://www.aerzteblatt.de/nachrichten/111618/Strategien-von-Tumorzellen-zur-Metastasenbildung

Baccin, C.*, Al-Sabah*, J., Velten, L.*@, Helbling, P. M., Grunschlager, F., Hernandez-Malmierca, P., Nombela-Arrieta, C., Steinmetz, L. M.@, Trumpp, A.@, & Haas, S.@ (2020). Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology. doi: 10.1038/s41556-019-0439-6 *Shared first authors, @ Joint Supervising authors