Solid Tumors and Metastasis

Solid Tumors, Metastasis & Therapy Resistance

Solid Tumors and Metastasis
Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia
Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment
HI-STEM Group Leaders

HI-STEM Group Leaders

HI-STEM Group Leaders
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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S, Doll SG, Schaefer EL, Ekpo I, Schmitz W, Horling A, Imming P, Miyamoto S, Wehman AM, Genaro-Mattos TC, Mirnics K, Kumar L, Klein-Seetharaman J, Meierjohann S, Weigand I, Kroiss M, Bornkamm GW, Gomes F, Netto LES, Sathian MB, Konrad DB, Covey DF, Michalke B, Bommert K, Bargou RC, Garcia-Saez A, Pratt DA, Fedorova M, Trumpp A, Conrad M, Friedmann Angeli JP. Nature. 2024 Feb;626(7998):401-410.

 

Our paper is highlighted in:

https://intranet.dkfz.de/artikel/cholesterin-vorstufe-schuetzt-krebszellen-vor-zelltod-und-macht-sie-aggressiver

https://aacrjournals.org/cdnews/news/1288/7-Dehydrocholesterol-Suppresses-Ferroptosis-and

 

 

 

 

Saini M, Schmidleitner L, Moreno HD, Donato E, Falcone M, Bartsch JM, Klein C, Vogel V, Würth R, Pfarr N, Espinet E, Lehmann M, Königshoff M, Reitberger M, Haas S, Graf E, Schwarzmayr T, Strom TM, Spaich S, Sütterlin M, Schneeweiss A, Weichert W, Schotta G, Reichert M, Aceto N, Sprick MR, Trumpp A, Scheel CH.

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer.
Cell Rep. 2023 May 30:112533. doi: 10.1016/j.celrep.2023.112533. Epub ahead of print. PMID: 37257449.

Waclawiczek A, Leppä AM, Renders S, Stumpf K, Reyneri C, Betz B, Janssen M, Shahswar R, Donato E, Karpova D, Thiel V, Unglaub JM, Grabowski S, Gryzik S, Vierbaum L, Schlenk RF, Röllig C, Hundemer M, Pabst C, Heuser M, Raffel S, Müller-Tidow C, Sauer T, Trumpp A.

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax.
Cancer Discov. 2023 Jun 2;13(6):1408-1427. doi: 10.1158/2159-8290.CD-22-0939. PMID: 36892565; PMCID: PMC10236156.