Solid Tumors and Metastasis

Solid Tumors, Metastasis & Therapy Resistance

Read more
Solid Tumors and Metastasis
Hematopoietic Stem Cells and Leukemia

Hematopoietic Stem Cells and Leukemia

Read more
Hematopoietic Stem Cells and Leukemia
Stem Cells and Tumor Microenvironment

Stem Cells and Tumor Microenvironment

Read more
Stem Cells and Tumor Microenvironment
The HI-STEM Team

The HI-STEM Team

HI-STEM features an interdisciplinary research team.
The HI-STEM Team
HI-STEM Group Leaders

HI-STEM Group Leaders

HI-STEM Group Leaders
Movie Slide

Watch the HI-STEM Movie!

Movie Slide
PlayPause
previous arrow
next arrow

Saini M, Schmidleitner L, Moreno HD, Donato E, Falcone M, Bartsch JM, Klein C, Vogel V, Würth R, Pfarr N, Espinet E, Lehmann M, Königshoff M, Reitberger M, Haas S, Graf E, Schwarzmayr T, Strom TM, Spaich S, Sütterlin M, Schneeweiss A, Weichert W, Schotta G, Reichert M, Aceto N, Sprick MR, Trumpp A, Scheel CH.

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer.
Cell Rep. 2023 May 30:112533. doi: 10.1016/j.celrep.2023.112533. Epub ahead of print. PMID: 37257449.

Waclawiczek A, Leppä AM, Renders S, Stumpf K, Reyneri C, Betz B, Janssen M, Shahswar R, Donato E, Karpova D, Thiel V, Unglaub JM, Grabowski S, Gryzik S, Vierbaum L, Schlenk RF, Röllig C, Hundemer M, Pabst C, Heuser M, Raffel S, Müller-Tidow C, Sauer T, Trumpp A.

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax.
Cancer Discov. 2023 Jun 2;13(6):1408-1427. doi: 10.1158/2159-8290.CD-22-0939. PMID: 36892565; PMCID: PMC10236156.

Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP. 

LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi:10.15252/emmm.202318014. Epub 2023 Jul 12. PMID: 37435859; PMCID: PMC10405063.

Ruzhica Bogeska, Ana-Matea Mikecin, Paul Kaschutnig, Malak Fawaz, Marleen Büchler-Schäff, Duy Le, Miguel Ganuza, Angelika Vollmer, Stella V. Paffenholz, Noboru Asada, Esther Rodriguez-Correa, Felix Frauhammer, Florian Buettner, Melanie Ball, Julia Knoch, Sina Stäble, Dagmar Walter, Amelie Petri, Martha J. Carreño-Gonzalez, Vinona Wagner, Benedikt Brors, Simon Haas, Daniel B. Lipka, Marieke A.G. Essers, Vivienn Weru, Tim Holland-Letz, Jan-Philipp Mallm, Karsten Rippe, Stephan Krämer, Matthias Schlesner, Shannon McKinney Freeman, Maria Carolina Florian, Katherine Y. King, Paul S. Frenette, Michael A. Rieger, Michael D. Milsom.

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging, Cell Stem Cell. 2022 Jul 12:S1934-5909(22)00261-2. doi: 10.1016/j.stem.2022.06.012. Online ahead of print. PMID: 35858618

 

Free access: https://authors.elsevier.com/a/1fRPY6tu0CiH2q