The German Research Foundation (DFG) will support the new Collaborative Research Center (SFB) 1709 “Cellular Plasticity in Malignant Myeloid Diseases – From Mechanism to Therapy” over the next four years. In around 20 working groups, scientists will investigate how and why certain leukemia cells change during the course of the disease and during therapy. The aim is to break their resistance to therapy in the future or prevent it from developing in the first place. HI-STEM managing director Prof. Dr. Andreas Trumpp is co-speaker of the collaborative research center and three HI-STEM group leaders are contributing to it with individual projects.

Mirco Julian Friedrich, Junior Group Leader at HI-STEM, DKFZ and Heidelberg University Hospital (UKHD) has been included in the prestigious Forbes list “30 Under 30 Europe” in the Science & Healthcare category.

The physician and cancer researcher, who has been heading the Junior Research Group Hematology and Immune Engineering since this year, initially developed successful approaches to reactivating the immune system against brain tumors.

With his current research, Friedrich aims to develop innovative strategies for reprogramming the human immune system by integrating synthetic immunology, genome editing, and AI-driven bioengineering. The goal is to prevent cancer, strengthen immune resilience, and promote healthy aging.

With this award, the US business magazine Forbes annually honors outstanding young people under the age of 30 who have made a mark in their fields through innovation, social relevance, and exceptional achievements.

To Mirco Friedrich's profile on the Forbes list

With his publication "Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging" in the Journal Cell Stem Cell, Aug 2022, Michael Milsom received the GSCN 2023 Publication of the Year Award. Big Congratulations!

 

  1. Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
  2. Gesucht wird MTA/BTA (m/w/d)
  3. How blood stem cells stay intact for a lifetime
  4. CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells
  5. Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs.
  6. Tumors on withdrawal: Amino acid deficiency shrinks childhood tumors
  7. ERC Advanced Grant for Andreas Trumpp
  8. High recognition for Andreas Trumpp
  9. Ferroptosis: Mechanism and Diseases
  10. Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells
  11. MutaSeq: Single-cell analysis of leukemic stem cells - Cooperation with Velten and Steinmetz Lab published in Nature Communications
  12. How blood stem cells maintain their lifelong potential for self-renewal - New publication in Nature Communications

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