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Research Group Normal and Malignant Stem Cells

Andreas Trumpp
Group Leader

 

I. Highlight Publications

February 14, 2024

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis (Nature, 2024)

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S,…
September 15, 2023

Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax (Cancer Discovery, 2023)

Waclawiczek A, Leppä AM, Renders S, Stumpf K, Reyneri C, Betz B, Janssen M, Shahswar R, Donato E, Karpova D, Thiel V, Unglaub JM, Grabowski S, Gryzik S, Vierbaum L, Schlenk RF, Röllig C, Hundemer M, Pabst C, Heuser M, Raffel S, Müller-Tidow C, Sauer T, Trumpp…
January 27, 2021

Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1 (Nature Communications, 2021)

Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P., Ladel, L., Redavid, A. R., Gibert, B., Lazare, S., Ducarouge, B., Schönberger, K., Narr, A., Tourbez, M., Dethmers-Ausema, B., Zwart, E., Hotz-Wagenblatt, A., Zhang, D.,…
October 15, 2020

Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin (Cancer Discovery, 2020)

Espinet, E.@, Gu, Z., Imbusch, C.D., Giese, N.A., Buscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., Insua-Rodriguez, J., Reitberger, M., Thiel, V., Kossi, S.O., Muckenhuber, A., Sarai, K., Lee, A.Y., Backx, E., Zarei, S., Gaida,…
March 30, 2020

Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism (Cell Stem Cell, 2020)

Sommerkamp, P., Altamura, S., Renders, S., Narr, A., Ladel, L., Zeisberger, P., Eiben, P.L., Fawaz, M., Rieger, M.A., Cabezas-Wallscheid, N., & Trumpp, A. (2020). Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation…
July 18, 2019
NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (blue), on the other hand, suppress NKG2DL expression at their surface and thus escape destruction by the immune system. © Schürch/Lengerke, University and University Hospital of Basel

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, 2019)

Paczulla, A.M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J.R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B.R., Caligiuri, M.A.,…

The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells (Scientific Reports, 2019)

Feb 14, 2019
Sommerkamp, P., Renders, S., Ladel, L., Hotz-Wagenblatt, A., Schönberger, K., Zeisberger,…

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies (Nature, 2018)

Jan 17, 2018
Bahr, C.*, von Paleske, L.*, Uslu, V.V.*, Remeseiro, S., Takayama, N., Ng, S.W., Murison,…

BCAT1 restrictsαKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Nature, 2017)

Nov 10, 2017
Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L.,…

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy (Cell, 2017)

May 18, 2017
Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L.,…

Human haematopoietic stem cell lineage commitment is a continuous process (Nature Cell Biology, 2017)

Mar 20, 2017
Velten, L.*, Haas, S.F.*, Raffel, S.*, Blaszkiewicz, S., Islam, S., Hennig, B.P., Hirche,…

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause (Cell, 2016)

Feb 16, 2016
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M.C., Altamura, S., Reyes, A.,…

Awakening dormant haematopoietic stem cells (Nature Reviews Immunology, 2010)

Mar 01, 2010
Trumpp, A., Essers, M., & Wilson, A. (2010). Awakening dormant haematopoietic stem cells.…

IFNalpha activates dormant haematopoietic stem cells in vivo (Nature, 2009)

Apr 16, 2009
Essers, M.A., Offner, S., Blanco-Bose, W.E., Waibler, Z., Kalinke, U., Duchosal, M.A., &…

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair (Cell, 2008)

Dec 12, 2008
Wilson, A., Laurenti, E., Oser, G., van der Wath, R.C., Blanco-Bose, W., Jaworski, M.,…

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity (Cell Stem Cell, 2008)

Dec 04, 2008
Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Bose, W.E., Ehninger,…

II. All Publications

Check out the publications authored by Andreas Trumpp on: